After Susan Murphy (voiced by Witherspoon) is struck by a meteor and grows to be 50-feet tall, she's captured by the government and shuttled to a secret compound where she meets a team of other monsters - soon to be Earth's only defense when an alien attacks. Under orders from the president (Colbert), Susan and her cohorts Dr. Cockroach (Laurie), the Missing Link (Arnett) and B.O.B. (Seth Rogen) set out to save the world.
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