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04194aam a2200409 a 4500 001 9C25F84808B011E8A8C4D83297128E48 003 SILO 005 20180203010326 008 081027t20092009sz ad b i000 0 eng d 020 $a 9241572396 020 $a 9789241572392 035 $a (OCoLC)264018462 040 $a BTCTA $c BTCTA $d YDXCP $d TPH $d SDB $d COD $d UtOrBLW $d SILO 060 14 $a QV 38 2009PR 245 00 $a Principles for modelling dose-response for the risk assessment of chemicals / $c first draft prepared by the WHO Task Group on Environmental Health Criteria on Principles for Modelling Dose-Response for the Risk Assessment of Chemicals. 264 1 $a Geneva, Switzerland : $b World Health Organization, $c [2009] 300 $a xx, 137 pages : $b illustrations, charts ; $c 21 cm. 490 1 $a Environmental health criteria, $x 0250-863X ; $v 239 504 $a Includes bibliographical references (pages 103-110). 500 $a "Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals." 520 3 $a This volume is part of the ongoing review of the underlying scientific bases for decision-making in chemical risk assessment by International Program on Chemical Safety. It involves specific consideration of the area of dose-response assessment in the evaluation of information from toxicological studies in animals and from human clinical and epidemiological studies. It covers toxicants with threshold effects and those for which there may be no practical threshold, such as substances that are genotoxic and carcinogenic. The discussions are concerned with that subset of cause-effect relationships commonly referred to as dose-response models, which are typically used to characterize the biological effects of intentional (e.g. drugs and nutrients) and unintentional (e.g. contaminants) exposure to chemicals. This report is intended primarily to provide descriptive guidance for risk assessors in using dose-response modeling in hazard characterization. It will also provide mathematical modelers with an appreciation of issues to be considered when modeling in the context of the risk assessment process. Risk managers will be able to obtain a general understanding of the applications and limitations of dose-response modeling. For both risk assessors and risk managers, some considerations for communicating the results of risk assessments that use dose-response modeling are presented.--Publisher's description. 505 2 $a Summary, conclusions, and recommendations -- Introduction -- Risk analysis -- Dose-response modelling : basic concepts -- Dose-response modelling : why and when to use it -- Principles of dose-response modelling -- Communicating the results of dose-response modelling -- Conclusions and recommendations. 650 0 $a Drugs $x Dose-response relationship. $0 http://id.loc.gov/authorities/subjects/sh85039728 650 0 $a Risk assessment. $0 http://id.loc.gov/authorities/subjects/sh87002638 650 12 $a Dose-Response Relationship, Drug. $2 [MeSH] $0 https://id.nlm.nih.gov/mesh/D004305 650 12 $a Dose-Response Relationship, Radiation. $2 [MeSH] $0 https://id.nlm.nih.gov/mesh/D004307 650 12 $a Risk Assessment. $2 [MeSH] $0 https://id.nlm.nih.gov/mesh/D018570 650 12 $a Environmental Exposure. $2 [MeSH] $0 https://id.nlm.nih.gov/mesh/D004781 710 2 $a World Health Organization. $0 http://id.loc.gov/authorities/names/n79059041 710 2 $a United Nations Environment Programme. $0 http://id.loc.gov/authorities/names/n80002388 710 2 $a International Labour Organisation. $0 http://id.loc.gov/authorities/names/n78095363 710 2 $a Inter-Organization Programme for the Sound Management of Chemicals. $0 http://id.loc.gov/authorities/names/n97036960 773 18 $w 990026579040202771 $g no:239 830 0 $a Environmental health criteria ; $v 239. $0 http://id.loc.gov/authorities/names/n42028282 941 $a 1 952 $l OVUX522 $d 20220317035925.0 956 $a http://locator.silo.lib.ia.us/search.cgi?index_0=id&term_0=9C25F84808B011E8A8C4D83297128E48Initiate Another SILO Locator Search