Includes bibliographical references (p. [129]-138) and index.
Contents:
Clinical trial basics -- Actionable prognostic biomarkers -- Phase II designs -- Enrichment designs -- Including both test positive and test negative patients -- Adaptive threshold design -- Multiple predictive biomarkers predictive analysis of clinical trials -- Prospective : retrospective design.
Summary:
"Genomics is having a major impact on therapeutics development in medicine. This book contains up-to-date information on the use of genomics in the design and analysis of therapeutic clinical trials with a focus on novel approaches that provide a reliable basis for identifying what kinds of patients are likely to benefit from the test treatment. It is oriented to both statisticians and clinical investigators"--P. [4] of cover.
Series:
Practical guides to biostatistics and epidemiology
This resource is supported by the Institute of Museum and Library Services under the provisions of the Library Services and Technology Act as administered by State Library of Iowa.