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Author:

Simon, Richard M., 1943-

Title:

Genomic clinical trials and predictive medicine / Richard M. Simon.

Publisher:

Cambridge University Press,

Copyright Date:

2013

Description:

xiii, 144 p. : ill. ; 26 cm.

Subject:

Clinical trials--Statistical methods.
Genomics--Statistical methods.
Tumor markers--Statistical methods.
Therapeutics, Experimental--Statistical methods.

Notes:

Includes bibliographical references (p. [129]-138) and index.

Contents:

Clinical trial basics -- Actionable prognostic biomarkers -- Phase II designs -- Enrichment designs -- Including both test positive and test negative patients -- Adaptive threshold design -- Multiple predictive biomarkers predictive analysis of clinical trials -- Prospective : retrospective design.

Summary:

"Genomics is having a major impact on therapeutics development in medicine. This book contains up-to-date information on the use of genomics in the design and analysis of therapeutic clinical trials with a focus on novel approaches that provide a reliable basis for identifying what kinds of patients are likely to benefit from the test treatment. It is oriented to both statisticians and clinical investigators"--P. [4] of cover.

Series:

Practical guides to biostatistics and epidemiology

ISBN:

1107401356 (pbk.)
9781107401358 (pbk.)
1107008808 (hardback)
9781107008809 (hardback)

OCLC:

(OCoLC)799010632

LCCN:

2012027613

Locations:

USUX851 -- Iowa State University - Parks Library (Ames)