Includes bibliographical references (pages 799-844) and index.
Contents:
Pt. I. Introduction -- Basic statistical concepts -- Basic design considerations -- Randomization and blinding -- Pt. II. Designs and their classifications -- Designs for clinical trials -- Designs for cancer clinical trials -- Classification of clinical trials -- Pt. III. Analysis of clinical data -- Analysis of continuous data -- Analysis of categorical data -- Censored data and interim analysis -- Sample size determination -- Pt. IV. Issues in evaluation -- Issues in efficacy evaluation -- Safety assessment -- Pt. V. Recent development -- Biomarkers and targeted clinical trials -- Trials for evaluating accuracy of diagnostic devices -- Statistical methods in translational medicine -- Adaptive clinical trial designs -- Traditional Chinese medicine -- Pt. VI. Conduct of clinical trials -- Preparation and implementation of a clinical protocol -- Data management of a clinical trial.
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