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03358aam a2200469 i 4500 001 5AFA7D26F79311E8BA923B1497128E48 003 SILO 005 20181204010734 008 180206t20182018mauab b 001 0 eng c 010 $a 2018002504 020 $a 0674971701 020 $a 9780674971707 035 $a (OCoLC)1023054801 040 $a MH/DLC $b eng $e rda $c DLC $d OCLCO $d OCLCF $d OCLCQ $d BDX $d HLS $d YDX $d OCLCO $d IUL $d OCLCO $d OBE $d CUT $d SILO 042 $a pcc 050 00 $a QR414.5 $b .S53 2018 060 4 $a QW 168.5.R18 082 00 $a 579.2/569 $2 23 100 1 $a Skalka, Anna M., $e author. 245 10 $a Discovering retroviruses : $b beacons in the biosphere / $c Anne Marie Skalka. 264 1 $a Cambridge, Massachusetts : $b Harvard University Press, $c 2018. 300 $a xi, 177 pages : $b color illustrations, color map ; $c 24 cm 504 $a Includes bibliographical references (pages 161-170) and index. 505 0 $a Introduction -- Early pioneers -- Amending the central dogma -- The origin of retroviruses -- Retroviruses and evolution -- Revealing the genetic basis of cancer -- HIV and the AIDS pandemic -- Epilogue. 520 $a When invading a host cell, viruses seize cell machinery to make copies of their own genes. The immune system recognizes the invasion. In contrast, retroviruses colonize host cells through the process of reverse transcriptase. Retroviruses open host cell DNA and graft in their retroviral RNA, integrating into the host genome. The immune system has difficulty recognizing or ridding of foreign DNA that has become its own. Discovering Retroviruses presents the history of retrovirus discovery. Skalka illuminates retroviruses' role in evolution, human health, and disease, from the first sighting at the end of the nineteenth century to recent use in genetic engineering. Retroviral sequences in the human genome mark sites where endogenous retrovirus integrated over six million years ago. The 100,000 pieces of retrovirus DNA are remnants from germ line cell invasions and total approximately eight percent of the human genome. Through investigation of animal and human retroviral sequences, we know retroviral mutations can lead to cancers and immunodeficiencies, including HIV and leukemia. Today, researchers harness retroviruses for use in gene delivery systems and precision medicine advances. Discovering Retroviruses offers a lively perspective on stories of the major pioneers of the past century and the extraordinary roads to their discoveries, and demonstrates the growing importance of genetics to modern biomedicine.-- $c Provided by publisher. 650 0 $a Retroviruses. 650 0 $a Retrovirus infections. 650 0 $a Viruses $x Evolution. 650 0 $a Medicine $x History. $x History. 650 7 $a Medicine $x Research. $2 fast $0 (OCoLC)fst01015059 650 7 $a Retrovirus infections. $2 fast $0 (OCoLC)fst01096403 650 7 $a Retroviruses. $2 fast $0 (OCoLC)fst01096406 650 7 $a Viruses $x Evolution. $2 fast $0 (OCoLC)fst01167776 650 2 $a Retroviridae. 650 2 $a Retroviridae Infections. 650 2 $a Viruses $x growth & development. 650 2 $a History of Medicine. 655 7 $a History. $2 fast $0 (OCoLC)fst01411628 941 $a 1 952 $l USUX851 $d 20200204024443.0 956 $a http://locator.silo.lib.ia.us/search.cgi?index_0=id&term_0=5AFA7D26F79311E8BA923B1497128E48 994 $a 92 $b IWAInitiate Another SILO Locator Search