International Symposium on Retinal Degenerations (17th : 2016 : Kyoto, Japan), author.
Title:
Retinal degenerative diseases : mechanisms and experimental therapy / John D. Ash, Robert E. Anderson, Matthew M. LaVail, Catherine Bowes Rickman, Joe G. Hollyfield, Christian Grimm, editors.
Publisher:
Springer,
Copyright Date:
2018
Description:
xlii, 669 pages : illustrations (some color) ; 25 cm.
"The XVII International Symposium on Retinal Degeneration (also known as RD2016) was held from September 19 to 24, 2016 ... in Kyoto, Japan"--Preface. Includes bibliographical references and index.
Contents:
Part 1. Age-related macular degeneration (AMD). Oxidative stress regulation and DJ-1 function in the retinal pigment epithelium: implications for AMD / Vera L. Bonilha -- Mitochondria: potential targets for protection in age-related macular degeneration / Emily E. Brown, Alfred S. Lewin, and John D. Ash -- Toll-like receptors and age-related macular degeneration / Kelly Mulfaul, Maedbh Rhatigan, and Sarah Doyle -- Alterations in extracellular matrix/Bruch's membrane can cause the activation of the alternative complement pathway via tick-over / Rosario Fernandez-Godino -- MicroRNA as therapeutics for age-related macular degeneration / Riccardo Natoli and Nilisha Fernando -- Anaphylatoxin signaling in retinal pigment and choroidal endothelial cells: characteristics and relevance to age-related macular degeneration / Bärber Rohrer -- Estimations of retinal blue-light irradiance values and melatonin suppression indices through clear and yellow-tinted intraocular lenses / Masaki Tanito [and 4 others] -- Co-expression of wild-type and mutant S163R C1QTNF5 in retinal pigment epithelium / Astra Dinculescu [and 6 others] -- part 2. Gene therapies. Mini-review: cell type-specific optogenetic vision restoration approaches / Antoine Chaffiol and Jens Duebel -- Mutation-independent gene therapies for rod-cone dystrophies / Cécile Fortuny and John G. Flannery -- Antisense oligonucleotide-based splice correction of a deep-intronic mutation in CHM underlying choroideremia / Alejandro Garanto [and 4 others] -- Gene therapy approaches to treat the neurodegeneration and visual failure in neuronal ceroid lipofuscinoses / Sophia-Martha kleine Holthaus, Alexander J. Smith, Sara E. Mole, and Robin R. Ali -- Success of gene therapy in late-stage treatment / Susanne F. Koch and Stephen H. Tsang -- Optimizing non-viral gene therapy vectors for delivery to photoreceptors and retinal pigment epithelial cells / Rahel Zulliger [and 6 others] -- Nanoparticles as delivery vehicles for the treatment of retinal degenerative diseases / Yuhong Wang, Ammaji Rajala, and Raju V.S. Rajala -- Overexpression of type 3 iodothyronine deiodinase reduces cone death in the Leber congenital amaurosis model mice / Fan Yang [and 4 others] -- part 3. In-vivo diagnostics for structure and function. In vivo functional imaging of retinal neurons using red and green fluorescent calcium indicators / Soon K. Cheong [and 5 others] -- Optimizing ERG measures of scotopic and photopic critical flicker frequency / Marci L. DeRamus and Timothy W. Kraft -- Repeatability and reproducibility of in vivo cone density measurements in the adult zebrafish retina / Alison Huckenpahler [and 4 others] -- Normative retinal thicknesses in common animal models of eye disease using spectral domain optical coherence tomography / Christy L. Carpenter, Alice Y. Kim, and Amir H. Kashani -- A novel approach for integrating AF-SLO and SDOCT imaging data demonstrates the ability to identify early retinal abnormalities in mutant mice and evaluate the effects of genetic and pharmacological manipulation / Brent A. Bell, Vera L. Bonilha, and Ivy S. Samuels -- part 4. Inflammation and angiogenesis. The role of hypoxia, hypoxia-inducible factor (HIF), and VEGF in retinal angiomatous proliferation / Maya Barben, Marijana Samardzija, and Christian Grimm -- Neuroinflammation in retinitis pigmentosa, diabetic retinopathy, and age-related macular degeneration: a minireview / Michael t. Massengill, Chulbul M. Ahmed, Alfred S. Lewin, and Cristhian J. Ildefonso -- Autoimmune retinopathy: an immunologic cellular-driven disorder / John R. Heckenlively and Steven K. Lundy -- Inflammation-induced photoreceptor cell death / Abdoulaye Sene and Rajendra S. Apte -- Sall1 regulates microglial morphology cell autonomously in the developing retina / Hideto Koso, Ryuichi Nishinakamura, and Sumiko Watanabe -- part 5. Inherited retinal degenerations. Whole-exome sequencing identifies novel variants that co-segregates with autosomal recessive retinal degeneration in a Pakistani pedigree / Pooja Biswas [and 8 others] -- Identification of novel deletions as the underlying cause of retinal degeneration in two pedigrees / Kari Branham [and 12 others] -- Molecular findings in families with an initial diagnose of autosomal dominant retinitis pigmentosa (adRP) / Stephen P. Daiger [and 9 others] -- Pleiotropic effects of risk factors in age-related macular degeneration and seemingly unrelated complex diseases / Christina Kiel, Bernhard H.F. Weber, and Felix Grassmann -- Mapping of canine models of inherited retinal diseases / Keiko Miyadera -- A mini-review: Leber congenital amaurosis: identification of disease-causing variants and personalised therapies / J.A. Thompson, J.N. De Roach, T.L. McLaren, and T.M. Laney -- part 6. Mechanisms of degeneration. Role of fibulins 2 and 5 in retinal development and maintenance / Larissa Ikelle, Muna I. Naash, and Muayyad R. Al-Ubaidi -- Identifying key networks linked to light-independent photoreceptor degeneration in visual arrestin 1 knockout mice / Hwa Sun Kim, Shun-Ping Huang, Eun-Jin Lee, and Cheryl Mae Craft -- How excessive cGMP impacts metabolic proteins in retinas at the onset of degeneration / Jianhai Du [and 4 others] -- Protein carbonylation-dependent photoreceptor cell death induced by N-Methyl-N-nitrosourea in mice / Ayako Furukawa, Kayo Sugitani, and Yoshiki Koriyama -- Müller glia reactivity and development of gliosis in response to pathological conditions / Anna B. Graca, Claire Hippert, and Rachael A. Pearson -- Underdeveloped RPE apical domain underlies lesion formation in canine bestrophinopathies / Karina E. Guziewicz [and 6 others] -- Binary function of ARL3-GTP revealed by gene knockouts / Christian Hanke-Gogokhia, Jeanne M. Frederick, Houbin Zhang, and Wolfgang Baehr -- Do cGMP levels drive the speed of photoreceptor degeneration? / Maria Iribarne and Ichiro Masai -- Early endosome morphology in health and disease / Gulpreet Kaur and Aparna Lakkaraju -- The retinal circadian clock and photoreceptor viability / Kenkichi Baba, Christophe P. Ribelayga, P. Michael Iuvone, and Gianluca Tosini -- The role of c-Jun N-terminal kinase (JNK) in retinal degeneration and vision loss / Byung-Jin Kim and Donald J. Zack -- The evaluation of BMI1 posttranslational modifications during retinal degeneration to understand BMI1 action on photoreceptor death execution / Martial K. Mbefo and Yvan Arsenijevic -- Primary rod and cone degeneration is prevented by HDAC inhibition / Dragana Trifunović [and 5 others] -- Impact of MCT1 haploinsufficiency on the mouse retina / Neal S. Peachey [and 6 others] -- The Leber congenital amaurosis-linked protein AIPL1 and its critical role in photoreceptors / Almudena Sacristan-Reviriego and Jacqueline van der Spuy -- Alternative splicing for activation of coagulation factor XIII-A in the fish retina after optic nerve injury / Kayo Sugitani [and 4 others] -- Bisretinoid photodegradation is likely not a good thing / Keiko Ueda, Hye Jin Kim, Jin Zhao, and Janet R. Sparrow -- Further characterization of the predominant inner retinal degeneration of aging Cln3[superscript][delta]ex7/8 knock-in mice / Cornelia Volz, Myriam Mirza, Thomas Langmann, and Herbert Jägle -- Differential exon expression in a large family of retinal genes is regulated by a single trans locus / Jiaxing Wang [and 6 others] -- Molecular chaperone ERp29: a potential target for cellular protection in retinal and neurodegenerative diseases / Todd McLaughlin, Marek Falkowski, Joshua J. Wang, and Sarah X. Zhang -- The role of microbiota in retinal disease / Sheldon Rowan and Allen Taylor -- part 7. Neuroprotection. Current pharmacological concepts in the treatment of the retinitis pigmentosa / Xiu-Feng Huang -- Valproic acid inhibits human retinal pigment epithelial (hRPE) cell proliferation via a P38 MAPK signaling mechanism / Rohit Anand, Piyush C. Kothary, and Monte A. Del Monte -- Pigment epithelium-derived factor protects retinal pigment epithelial cells against cytotoxicity "in vitro" / Francisco M. Nadal-Nicolas and S. Patricia Becerra -- Brain-derived neurotrophic factor as a treatment option for retinal degeneration / Conor Daly [and 5 others] -- VEGF as a trophic factor for Müller glia in hypoxic retinal diseases / Shuhua Fu, Shuqian Dong, Meili Zhu, and Yun-Zheng Le -- Müller cell biological processes associated with leukemia inhibitory factor expression / Marcus J. Hooper and John D. Ash -- Retbindin is capable of protecting photoreceptors from flavin-sensitized light-mediated cell death in vitro / Ryan A. Kelley, Muayyad R. Al-Ubaidi, and Muna I. Naash -- Constitutive activation mutant mTOR promote cone survival in retinitis pigmentosa mice / Ammaji Rajala, Yuhong Wang, and Raju V.S. Rajala -- Maintaining cone function in rod-cone dystrophies / José-Alain Sahel and Thierry Léveillard -- PKG-dependent cell death in 661W cone photoreceptor-like cell cultures (experimental study) / Stine Mencl, Dragana Trifunović, Eberhart Zrenner, and François Paquet-Durand -- part 8. Retinal cell biology. More than meets the eye: current understanding of RPGR function / Hemant Khanna -- Polarized exosome release from the retinal pigmented epithelium / Mikael Klingeborn, W. Daniel Stamer, and Catherine Bowes Rickman -- The impact of adherens and tight junctions on physiological function and pathological changes in the retina / Yang Kong, Jürgen K. Naggert, and Patsy M. Nishina -- TRPV4 does not regulate the distal retinal light response / Oleg Yarishkin, Tam T.T. Phuong, Monika Lakk, and David Križaj -- Role of sirtuins in retinal function under basal conditions / Jonathan B. Lin, Shunsuke Kubota, Raul Mostoslavsky, and Rajendra S. Apte -- The retinol-binding protein receptor 2 (Rbpr2) is required for photoreceptor survival and visual function in the zebrafish / Glenn P. Lobo, Gayle Pauer, Joshua H. Lipschutz, and Stephanie A. Hagstrom -- Opposite roles of MerTK ligands Gas6 and protein S during retinal phagocytosis / Emeline F. Nandrot -- Redundant and nonredundant functions of Akt isoforms in the retina / Raju V.S. Rajal and Ammaji Rajala -- Photoreceptor outer segment isolation from a single canine retina for RPE phagocytosis assay / Raghavi Sudharsan [and 4 others] -- Preservation of photoreceptor nanostructure for electron tomography using transcardiac perfusion followed by high-pressure freezing and freeze-substitution / Stefanie Volland and David S. Williams -- Microtubule-associated protein 1 light chain 3 (LC3) Isoforms in RPE and retina / Anuradha Dhingra [and 4 others] -- part 9. Stem cells. The iPSc-derived retinal tissue as a tool to study growth factor production in the eye / Maryam Alavi and Petr Baranov -- Stem cell-based RPE therapy for retinal diseases: engineering 3D tissues amenable for regenerative medicine / Karim Ben M'Barek, Walter Habeler, and Christelle Monville -- Validation of iPS cell-derived RPE tissue in animal models / Vladimir Khristov [and 5 others] -- Cell transplantation for retinal degeneration: transition from rodent to nonhuman primate models / Trevor J. McGill [and 4 others] -- Talaumidin promotes neurite outgrowth of staurosporine-differentiated RGC-5 cells through PI3K/Akt-dependent pathways / Yoshiki Koriyama [and 5 others].
Summary:
"The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the "best" and "most important" meetings in the field. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy. While advances in these areas of retinal degenerations will be described, there will be many new topics that either were in their infancy or did not exist at the time of the last RD Symposium, RD2014. These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those will be reported at the RD2018 meeting and included in the proposed volume. We anticipate the excitement of those working in the field and those afflicted with retinal degenerations will be reflected in the volume"--Publisher's description.
Series:
Advances in experimental medicine and biology, 0065-2598 ; 1074
This resource is supported by the Institute of Museum and Library Services under the provisions of the Library Services and Technology Act as administered by State Library of Iowa.