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03441aam a2200469Ii 4500 001 C4C34028FF7E11E48613ECADDAD10320 003 SILO 005 20150521010053 008 140627s2015 nyua b 001 0 eng d 020 $a 9780142181843 (pbk.) 020 $a 0142181846 035 $a (OCoLC)881869810 040 $a YDXCP $b eng $e rda $c YDXCP $d OCLCQ $d BTCTA $d BDX $d EXR $d OCLCF $d LS@ $d SILO 043 $a e-gx--- 082 $a 616.9792 $b H742c 2015 100 1 $a Holt, Nathalia, $d 1980- $e author. 245 10 $a Cured : $b the people who defeated HIV / $c Nathalia Holt. 264 1 $a New York, New York : $b Plume, Published by the Penguin Group, $c 2015. 300 $a xxi, 313 pages : $b illustrations ; $c 21 cm 500 $a First published in the United States of America by Dutton, 2014. 504 $a Includes bibliographical references and index. 505 0 $a A doctor, two patients, and some tests. The good doctor in denial ; A visit with the family doctor ; Death sentence? -- The disease, a drug, and its industry. Viral Trojan horse ; A weapon from the war on cancer ; The days of acting up ; Recognizing a global pandemic ; From the one percent ; But, Doctor, I don't feel sick ; The Delta 32 Mutation ; Calling all elite controllers ; Treatment in hiding -- Treating the Berlin patients. The second diagnosis ; The compassionate use exemption ; Three deadly diseases move in ; The comfort of family and strangers ; Timing ; Transplanting ; "Perhaps we have eradicated HIV" ; An unexciting recovery -- The cure. Trials ; Proof of principle ; The good doctor in court ; Not even surprising ; The promise kept ; A child cured-- so what? ; Zinc finger snap ; The abused, the respected, the relentless. 520 $a A young molecular biologist at the forefront of HIV research, Nathalia Holt tells the historic, multilayered, and compassionate story of two patients--each known in medical literature as the Berlin Patient--and their young research-minded doctors. The backdrop is nothing less than a revolution in cultural attitudes and medical thinking. These two patients' disparate cures came twelve years apart: the first in 1996 from an experimental cancer drug, the other in 2008 from a bone marrow transplant of cells with a particular genetic mutation. Holt connects the molecular dots of these two cases for the first time, providing insight into one of the most important medical breakthroughs of our generation.--From publisher description. 650 0 $a HIV infections $x Treatment $z Berlin. $z Berlin. 650 0 $a Gene therapy $z Berlin $z Berlin $x History. 650 12 $a HIV Infections $x therapy $z Germany. 650 22 $a Anti-HIV Agents $x history $z Germany. 650 22 $a Anti-HIV Agents $x therapeutic use $z Germany. 650 22 $a Genetic Therapy $x history $z Germany. 650 22 $a History, 20th Century $z Germany. 650 22 $a History, 21st Century $z Germany. 650 22 $a Hydroxyurea $x history $z Germany. 650 22 $a Hydroxyurea $x therapeutic use $z Germany. 650 22 $a Treatment Outcome $z Germany. 650 7 $a Gene therapy. $0 (OCoLC)fst00939638. $2 fast 650 7 $a HIV infections $x Treatment. $0 (OCoLC)fst00949907. $2 fast 651 7 $a Germany $z Berlin. $0 (OCoLC)fst01204829. $2 fast 655 7 $a History. $0 (OCoLC)fst01411628. $2 fast 941 $a 2 952 $l DPPE403 $d 20240611021916.0 952 $l KSPG296 $d 20150618010321.0 956 $a http://locator.silo.lib.ia.us/search.cgi?index_0=id&term_0=C4C34028FF7E11E48613ECADDAD10320Initiate Another SILO Locator Search