"Applications in drug discovery"--Cover. Includes bibliographical references and index.
Contents:
Mass spectrometry in early pharmacokinetic investigations / Walter A. Korfmacher. Drug screening using gel permeation chromatography spin columns coupled with ESI-MS / Marshall M. Siegel -- ALIS : an affinity selection mass spectrometry system for the discovery and characterization of protein/ligand interactions / Allen Annis, Cheng-Chi Chuang, Naim Nazef -- Library screening using ultrafiltration and mass spectrometry / Timothy E. Cloutier, Kenneth M. Comess -- Continuous flow systems for ligand binding and enzyme inhibition assays based on mass spectrometry / Hubertus Irth -- Frontal affinity chromatography : mass spectrometry for ligand discovery and characterization / Nora Chan, Darren Lewis, Michele Kelly, Ella S. M. Ng, David C. Schriemer -- MS binding assays : an alternative to radioligand binding / Georg Hofner, Christine Zepperitz, Klaus T. Wanner -- Laser desorption assays : MALDI-MS, DIOS-MS, and SAMDI-MS / Martin Vogel, Andy Scheffer, Andre Liesener, Uwe Karst -- Tethering : fragment based drug discovery by mass spectrometry / Mark T. Concilla, Daniel A. Erlanson -- Interrogation of noncovalent complexes by ESI-MS : a powerful platform for high throughput drug discovery / Steven A. Hofstadler, Kristin A. Sannes-Lowery -- Quantification of protein/ligand interactions in solution by hydrogen/deuterium exchange (PLIMSTEX) / Mei M. Zhu, David Hambly, Michael L. Gross -- Protein targeting drug discovery guided by hydrogen/deuterium exchange mass spectrometry (DXMS) / Yoshitomo Hamuro, Stephen J. Coales, Virgil L. Woods, Jr. -- Mass spectrometry in early pharmacokinetic investigations / Walter A. Korfmacher.
Series:
Methods and principles in medicinal chemistry v. 36
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