General toxicology. Developing combination drugs in preclinical studies / Alberto Lodola -- Preclinical evaluation of juvenile toxicity / Paul C. Barrow, Stéphane Barbellion, and Jeanne Stadler -- Pathology. Necropsy and sampling procedures in rodents / Laurence Fiette and Mohamed Slaoui -- Histopathology procedures : from tissue sampling to histopathological evaluation / Mohamed Slaoui and Laurence Fiette -- Principles and methods of immunohistochemistry / José A. Ramos-Vara -- Tissue microarrays and digital image analysis / Denise Ryan ... [et al.] -- Genetic toxicology. Micronucleus assay and labeling of centromeres with FISH technique / Ilse Decordier, Raluca Mateuca, and Micheline Kirsch-Volders -- The use of bacterial repair endonucleases in the comet assay / Andrew R. Collins -- Safety pharmacology. Manual whole-cell patch-clamping of the HERG cardiac K⁺ channel / Xiao-Liang Chen, Jiesheng Kang, and David Rampe -- Investigative toxicology. Generation and analysis of transcriptomics data / Philip D. Glaves and Jonathan D. Tugwood -- Protocols of two-dimensional difference gel electrophoresis to investigate mechanisms of toxicity / Emmanuelle Com ... [et al.] -- Protocols and applications of cellular metabolomics in safety studies using precision-cut tissue slices and carbon 13 NMR / Gabriel Baverel ... [et al.] -- Statistical analysis of quantitative RT-PCR results / Richard Khan-Malek and Ying Wang -- Evaluation of mitochondrial respiration in cultured rat hepatocytes / Jean-Pierre Marchandeau and Gilles Labbe -- Screening assays for developmental toxicity. FETAX assay for evaluation of developmental toxicity / Isabelle Mouche, Laure Malesic, and Olivier Gillardeaux -- Evaluation of embryotoxicity using the zebrafish model / Lisa Truong, Stacey L. Harper, and Robert L. Tanguay -- Chemical protein adducts. Protocols of in vitro protein covalent binding studies in liver / Jean-François Lévesque, Stephen H. Day, and Allen N. Jones -- Utilization of MALDI-TOF to determine chemical-protein adduct formation in vitro / Ashley A. Fisher ... [et al.] -- Utilization of LC-MS/MS analyses to identify site-specific chemical protein adducts in vitro / Ashley A. Fisher ... [et al.] -- One-dimensional western blotting coupled to LC-MS/MS analysis to identify chemical-adducted proteins in rat urine / Matthew T. Labenski ... [et al.] -- Identification of chemical-adducted proteins in urine by multi-dimensional protein identification technology (LC/LC-MS/MS) / Matthew T. Labenski ... [et al.] -- Safety biomarkers. Optimization of SELDI for biomarker detection in plasma / Jean-Francois Léonard, Martine Courcol, and Jean-Charles Gautier -- Differential proteomics incorporating iTRAQ labeling and multi-dimensional separations / Ben C. Collins ... [et al.] -- NMR and MS methods for metabonomics / Frank Dieterle ... [et al.] -- Absolute quantification of toxicological biomarkers by multiple reaction monitoring / Thomas Y. K. Lau ... [et al.].
Series:
Methods in molecular biology, 1064-3745 ; 691 Spinger protocols
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