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02242cam a2200325Ka 4500 001 0CA38642FBCE11DEB3E93EDF5F36B428 003 SILO 005 20100120073657 008 090819s2009 dcua b 100 0 eng d 020 $a 0309131243 (pbk.) 020 $a 9780309131247 (pbk.) 035 $a (OCoLC)431872188 040 $a YDXCP $c YDXCP $d SILO $d IWA $d SILO 245 0 $a Accelerating the development of biomarkers for drug safety : $b workshop summary / $c Steve Olson, Sally Robinson and Robert Giffin, rapporteurs ; Forum on Drug Discovery, Development, and Translation, Board on Health Sciences Policy, Institute of Medicine of the National Academies. 260 $a Washington, D.C. : $b National Academies Press, $c c2009. 300 $a xv, 83 p. : $b ill. ; $c 23 cm. 504 $a Includes bibliographical references. 505 0 $a Introduction -- Overview Of key issues -- Cardiac safety biomarkers -- Assessing and predicting kidney safety -- Biomarkers of acute idiosyncratic hepatocellular injury in clinical trials -- Future considerations. 520 $a "Biomarkers can be defined as indicators of any biologic state, and they are central to the future of medicine. As the cost of developing drugs has risen in recent years, reducing the number of new drugs approved for use, biomarker development may be a way to cut costs, enhance safety, and provide a more focused and rational pathway to drug development. On October 24, 2008, the IOM's Forum on Drug Discovery, Development, and Translation held 'Assessing and Accelerating Development of Biomarkers for Drug Safety,' a one-day workshop, summarized in this volume, on the value of biomarkers in helping to determine drug safety during development."--Publisher's website. 650 0 $a Biochemical markers $v Congresses. 650 0 $a Drugs $x Safety measures $v Congresses. 650 0 $a Drugs $x Testing $v Congresses. 700 1 $a Olson, Steve, $d 1956- 700 1 $a Robinson, Sally. 700 1 $a Giffin, Robert B. 710 2 $a Institute of Medicine (U.S.). $b Forum on Drug Discovery, Development, and Translation. 941 $a 1 952 $l USUX851 $d 20160824031251.0 956 $a http://locator.silo.lib.ia.us/search.cgi?index_0=id&term_0=0CA38642FBCE11DEB3E93EDF5F36B428 994 $a 02 $b IWAInitiate Another SILO Locator Search