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Title:

Huntington's disease / edited by Sophie V. Precious, Anne E. Rosser, and Stephen B. Dunnett.

Publisher:

Humana Press :

Copyright Date:

2018

Description:

xv, 642 pages : illustrations (some color) ; 27 cm.

Subject:

Huntington's disease--Laboratory manuals.
Huntington's disease.
Laboratory manuals.
Laboratory manuals.

Other Authors:

Precious, Sophie V., editor.
Rosser, Anne E., editor.
Dunnett, S. B. (Stephen B.), editor.

Notes:

Includes bibliographical references and index.

Contents:

Quality assessment and production of human cells for clinical use / Lindsay Fraser, Kevin Bruce, John M. Campbell, and Paul A. De Sousa. Assessing autophagic activity and aggregate formation of mutant huntingtin in mammalian cells / Eleanna Stamatakou, Ye Zhu, and David C. Rubinsztein -- Filter retardation assay facilitates the detection and quantification of heat-stable, amyloidogenic mutant huntingtin aggregates in complex biosamples / Anne Ast, Franziska Schindler, Alexander Buntru, Sigrid Schnoegl, and Erich E. Wanker -- Cellular models : HD patient-derived pluripotent stem cells / Charlene Geater, Sarah Hernandez, Leslie Thompson, and Virginia B. Mattis -- Nonmammalian models of Huntington's Disease / Anjalika Chongtham, Brett Barbaro, Tomas Filip, Adeela Syed, Weijian Huang, Marianne R. Smith, and J. Lawrence Marsh -- Mouse models of Huntington's Disease / Pamela P. Farshim and Gillian P. Bates -- Motor assessment in Huntington's Disease mice / Stephen B. Dunnett and Simon P. Brooks -- Automated operant assessments of Huntington's Disease mouse models / Emma Yhnell and Andreas Heuer -- Neurophysiological assessment of Huntington's Disease model mice / Elissa J. Donzis, Sandra M. Holley, Carlos Cepeda, and Michael S. Levine -- Murine models of Huntington's Disease for evaluating therapeutics / Natalia Kosior and Blair R. Leavitt -- Generating excitotoxic lesion models of Huntington's Disease / Mariah J. Lelos and Stephen B. Dunnett -- Large-brained animal models of Huntington's Disease : sheep / A. Jennifer Morton -- Minipigs as a large-brained animal model for Huntington's Disease : from behavior and imaging to gene therapy / Ralf Reilmann and Verena Schuldenzucker -- Nonhuman primate models of Huntington's Disease and their application in translational research / Romina Aron Badin -- In vivo multidimensional brain imaging in Huntington's Disease animal models / Julien Flament, Philippe Hantraye, and Julien Valette -- Magnetic resonance imaging in Huntington's Disease / Sarah Gregory, Rachael I. Scahill, Geraint Rees, and Sarah Tabrizi -- Biofluid biomarkers in Huntington's Disease / Filipe B. Rodrigues, Lauren M. Byrne, and Edward J. Wild -- Assessing and modulating kynurenine pathway dynamics in Huntington's Disease : focus on kynurenine 3-monooxygenase / Korrapati V. Sathyasaikumar, Carlo Breda, Robert Schwarcz, and Flaviano Giorgini -- Assessing mitochondrial function in in vitro and ex vivo models of Huntington's Disease / I. Luísa Ferreira, Catarina Carmo, Luana Naia, Sandra I. Mota, and A. Cristina Rego -- Using genomic data to find disease-modifying loci in Huntington's Disease (HD) / Peter Holmans and Tim Stone -- CRISPR/Cas9-mediated genome editing for Huntington's Disease / Gabriel Vachey and Nicole Déglon -- Methods for assessing DNA repair and repeat expansion in Huntington's Disease / Thomas Massey, Branduff McAllister, and Lesley Jones -- Translating antisense technology into a treatment for Huntington's Disease / Roger M. Lane, Anne Smith, Tiffany Baumann, Marc Gleichmann, Dan Norris, C. Frank Bennett, and Holly Kordasiewicz -- Disease modification through trophic factor delivery / Mari Savolainen, Dwaine Emerich, and Jeffrey H. Kordower -- Methods to quantify cell signaling and GPCR receptor ligand bias : characterization of drugs that target the endocannabinoid receptors in Huntington's Disease / Amina M. Bagher, Robert B. Laprairie, Melanie E. M. Kelly, and Eileen M. Denovan-Wright -- Dissection and preparation of human primary fetal ganglionic eminence tissue for research and clinical applications / Victoria H. Roberton, Anne E. Rosser, Anne-Marie McGorrian, and Sophie V. Precious -- Robust induction of DARPP32-expressing GABAergic striatal neurons from human pluripotent stem cells / Marija Fjodorova and Meng Li -- Quality assessment and production of human cells for clinical use / Lindsay Fraser, Kevin Bruce, John M. Campbell, and Paul A. De Sousa.

Series:

Methods in molecular biology, 1064-3745 ; volume 1780
Springer protocols, 1949-2448

ISBN:

9781493978243
1493978241

OCLC:

(OCoLC)1022085172

LCCN:

2018939547

Locations:

OVUX522 -- University of Iowa Libraries (Iowa City)