Prolactin (PRL) in adipose tissue: regulation and functions / Nira Ben-Jonathan and Eric Hugo -- Signaling pathways regulating pituitary lactotrope homeostasis and tumorigenesis / Allyson K. Booth and Arthur Gutierrez-Hartmann -- The many faces of prolactin in breast cancer / Wen Y Chen -- Regulation of blood vessels by prolactin and vasoinhibins / Carmen Clapp, Stéphanie Thebault, Yazmín Macotela, Bibiana Moreno-Carranza, Jakob Triebel and Gonzalo Martínez de la Escalera -- Tyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion / Alan Hammer and Maria Diakonova -- Plasticity of the prolactin (PRL) axis: mechanisms underlying regulation of output in female mice / P. R. Le Tissier, D. J. Hodson, A. O. Martin, N. Romanò and P. Mollard -- Role of Src family kinases in prolactin signaling / Jorge Martín-Pérez, José Manuel García-Martínez, María Pilar Sánchez-Bailón, Víctor Mayoral-Varo and Annarica Calcabrini -- Prolactin-induced protein in breast cancer / Ali Naderi -- Modeling prolactin actions in breast cancer in vivo: insights from the NRL-PRL mouse / Kathleen A. O'Leary, Michael P. Shea and Linda A. Schuler -- Prolactin-induced prostate tumorigenesis / Lucila Sackmann-Sala and Vincent Goffin -- Prolactin in inflammatory response / Ana Laura Pereira Suarez, Gonzalo López-Rincón, Priscila A. Martínez Neri and Ciro Estrada-Chávez -- A positive feedback loop between prolactin and STAT5 promotes angiogenesis / Xinhai Yang and Andreas Friedl.
Summary:
"Recent Advances in Prolactin Research summarizes the current knowledge of prolactin (PRL), PRL receptor, PRL-dependent signaling pathways, the role of PRL in oncogenesis and PRL crosstalk with other oncogenic factors. The chapters are written by experts in these fields and focus on identifying and reviewing timely experimental findings that provide new insights into the expanding role of PRL in the pathophysiology associated with a variety of human conditions. Prolactin is a peptide hormone that is best known for its role in lactation. Prolactin also has an influence on hematopoiesis and angiogenesis, and is involved in the regulation of blood clotting through several pathways. Although PRL was discovered more than 80 years ago, the understanding of PRL signaling and its relationship to various pathologies is still very incomplete. PRL is not only a pituitary hormone with an important role in reproduction, but PRL also acts as a cytokine, modulating a wide variety of physiological processes. For example, data gathered during the last decade have demonstrated that locally produced PRL acts as the autocrine/paracrine factor and plays a contributory role during breast oncogenesis. In fact, the scientific and clinical communities have suggested that the manipulation of the PRL axis may lead to the successful treatment of breast cancer. However, recent work has demonstrated that the role of the PRL axis is much more complex than first envisaged"--Publisher's description.
Series:
Advances in experimental medicine and biology, 0065-2598 ; volume 846
This resource is supported by the Institute of Museum and Library Services under the provisions of the Library Services and Technology Act as administered by State Library of Iowa.