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Author:

Vasquez, Alex.

Title:

Human microbiome and dysbiosis in clinical disease : an integrative functional medicine approach to understanding and treating microbial imbalances and chronic infections / Alex Vasquez.

Publisher:

International College of Human Nutrition & Functional Medicine,

Copyright Date:

2015

Description:

xiv, 144, 118 pages : illustrations ; 28 cm

Subject:

Medical microbiology.
Infection.
Infection.
Medical microbiology.
Microbiota.
Dysbiosis--therapy.
Anti-Infective Agents.

Notes:

Peer-reviewed monograph for continuing education program. Volume 1: parts 1-4 - cover.

Contents:

Section 1: Infections & dysbiosis: subclinical infections & persistent microbial colonization. 1. Molecules from microbes that promote disease (and health) -- Gram-negative bacterial products, LPS -- Gram-positive bacterial products -- L-form, pleomorphic, "cell wall-deficient" bacteria -- Immunostimulation by bacterial DNA, viral DNA -- Superantigens -- Antimetabolites -- Beneficial metabolites and molecular signatures -- 2. Mechanisms of dysbiosis/colonization in clinical disease -- Damage to the intestinal mucosa -- Activation of inflammatory pathways -- TLR, NFkB, DAMP/PAMP -- Mitochondrial hyperpolarization, mTOR activation -- Molecular mimicry, cross-reactivity -- Enhanced presentation of autoantigens -- Bystander activation -- Haptenization and the formation of neoautoantigens -- Immune complex formation and disposition -- Insufficiency dysbiosis -- Microbial allergy, hypersensitivity -- Inhibition of detoxification -- Bacterial and fungal proteases impair immune defenses -- Immunosuppression via gliotoxins -- Mold toxins -- mycotoxins -- Biofilms -- Impairment of mucosal digestion -- Central sensitization, microbiome-gut-brain axis -- Dysbiosis-induced endocrine dysfunction -- Microbe-induced epigenetic changes -- Altered vitamin D metabolism and reception -- 3. Prototypic microbe-disease clinical presentations -- Autointoxication, auto-brewery syndrome, encephalopathy -- Syndromes of pain, fatigue, depression -- Dysbiotic arthropathy, dermatitis, vasculitis -- Reactive arthritis -- 4. Locations of dysbiosis, introduction to the viral microbiome -- Review questions -- Index to text section -- Section 2. Presentation slides and diagrams.

ISBN:

1512360295
9781512360295

OCLC:

(OCoLC)935942346

Locations:

LVOX826 -- Palmer College of Chiropractic (Davenport)