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04611aam a2200409Ii 4500 001 ACF80656F2F211E49475ABD7DAD10320 003 SILO 005 20150505014724 008 140908t20152015sz a b 000 0 eng d 020 $a 3319121146 020 $a 9783319121147 020 $a 3319121138 020 $a 9783319121130 035 $a (OCoLC)890168273 040 $a YDXCP $b eng $c YDXCP $d BTCTA $d OCLCQ $d OCLCO $d CDX $d MMU $d SILO 050 4 $a QP572.P74 $b R43 2015 060 4 $a WK 515 082 04 $a 573.4/54 $2 23 245 00 $a Recent advances in prolactin research / $c Maria Diakonova, editor. 264 1 $a Cham [Switzerland] : $b Springer, $c [2015] 300 $a viii, 282 pages : $b illustrations (chiefly color) ; $c 24 cm. 490 1 $a Advances in experimental medicine and biology, $x 0065-2598 ; $v volume 846 504 $a Includes bibliographical references and index. 505 0 $a Prolactin (PRL) in adipose tissue: regulation and functions / Nira Ben-Jonathan and Eric Hugo -- Signaling pathways regulating pituitary lactotrope homeostasis and tumorigenesis / Allyson K. Booth and Arthur Gutierrez-Hartmann -- The many faces of prolactin in breast cancer / Wen Y Chen -- Regulation of blood vessels by prolactin and vasoinhibins / Carmen Clapp, SteÌphanie Thebault, YazmiÌn Macotela, Bibiana Moreno-Carranza, Jakob Triebel and Gonzalo MartiÌnez de la Escalera -- Tyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion / Alan Hammer and Maria Diakonova -- Plasticity of the prolactin (PRL) axis: mechanisms underlying regulation of output in female mice / P. R. Le Tissier, D. J. Hodson, A. O. Martin, N. RomanoÌ and P. Mollard -- Role of Src family kinases in prolactin signaling / Jorge MartiÌn-PeÌrez, JoseÌ Manuel GarciÌa-MartiÌnez, MariÌa Pilar SaÌnchez-BailoÌn, ViÌctor Mayoral-Varo and Annarica Calcabrini -- Prolactin-induced protein in breast cancer / Ali Naderi -- Modeling prolactin actions in breast cancer in vivo: insights from the NRL-PRL mouse / Kathleen A. O'Leary, Michael P. Shea and Linda A. Schuler -- Prolactin-induced prostate tumorigenesis / Lucila Sackmann-Sala and Vincent Goffin -- Prolactin in inflammatory response / Ana Laura Pereira Suarez, Gonzalo LoÌpez-RincoÌn, Priscila A. MartiÌnez Neri and Ciro Estrada-ChaÌvez -- A positive feedback loop between prolactin and STAT5 promotes angiogenesis / Xinhai Yang and Andreas Friedl. 520 $a "Recent Advances in Prolactin Research summarizes the current knowledge of prolactin (PRL), PRL receptor, PRL-dependent signaling pathways, the role of PRL in oncogenesis and PRL crosstalk with other oncogenic factors. The chapters are written by experts in these fields and focus on identifying and reviewing timely experimental findings that provide new insights into the expanding role of PRL in the pathophysiology associated with a variety of human conditions. Prolactin is a peptide hormone that is best known for its role in lactation. Prolactin also has an influence on hematopoiesis and angiogenesis, and is involved in the regulation of blood clotting through several pathways. Although PRL was discovered more than 80 years ago, the understanding of PRL signaling and its relationship to various pathologies is still very incomplete. PRL is not only a pituitary hormone with an important role in reproduction, but PRL also acts as a cytokine, modulating a wide variety of physiological processes. For example, data gathered during the last decade have demonstrated that locally produced PRL acts as the autocrine/paracrine factor and plays a contributory role during breast oncogenesis. In fact, the scientific and clinical communities have suggested that the manipulation of the PRL axis may lead to the successful treatment of breast cancer. However, recent work has demonstrated that the role of the PRL axis is much more complex than first envisaged"--Publisher's description. 650 0 $a Prolactin. 650 0 $a Prolactin $x Physiological effect. 650 0 $a Prolactin $x Pathophysiology. 650 12 $a Prolactin. $2 [MeSH] 650 22 $a Receptors, Prolactin. $2 [MeSH] 650 22 $a Signal Transduction. $2 [MeSH] 650 22 $a Neoplasms $x etiology. $2 [MeSH] 776 08 $i Online version: $t Recent advances in prolactin research. $d Cham : Springer, 2015 $z 9783319121147 $w (OCoLC)897810239 830 0 $a Advances in experimental medicine and biology ; $v v. 846. $x 0065-2598 941 $a 1 952 $l OVUX522 $d 20180110040205.0 956 $a http://locator.silo.lib.ia.us/search.cgi?index_0=id&term_0=ACF80656F2F211E49475ABD7DAD10320Initiate Another SILO Locator Search