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04028aam a22004817i 4500 001 C5E36EEC90F111EA86A69E4897128E48 003 SILO 005 20200508010100 008 170310s2017 ne b 001 0 eng d 010 $a 2017936545 020 $a 0128127961 020 $a 9780128127964 035 $a (OCoLC)974698870 040 $a BTCTA $b eng $e rda $c DLC $d BTCTA $d YDX $d BDX $d GSU $d WSU $d OCLCO $d OCLCF $d OCLCO $d OCLCQ $d TFW $d OCLCO $d USU $d OCLCO $d OCLCA $d DCK $d OCLCO $d GILDS $d UKMGB $d SILO 042 $a lccopycat 050 00 $a R850 $b .M27 2017 060 4 $a W 20.5 $b M311r 2017 082 04 $a 510.72 $2 23 100 1 $a Marangos, Paul J., $e author. 245 12 $a A roadmap for curing cancer, Alzheimer's, and cardiovascular disease / $c Paul J. Marangos. 264 1 $a Amsterdam ; $b Elsevier, $c [2017] 300 $a xv, 143 pages ; $c 23 cm 520 $a Cancer, dementia, and cardiovascular disease are responsible for almost two million deaths each year in the United States alone and represent the largest immediate threat to humanity. Over the last century, we have made spectacular advances that have transformed our society - splitting the atom, space travel, telecommunications, and the Internet - but with medical research focused mostly on science for the sake of science, it has yielded precious few cures. A Roadmap for Curing Cancer, Alzheimer's, and Cardiovascular Disease represents a "first of its kind" effort to address both the reasons for this and to posit solutions to fix our broken system, in an effort to finally end this cure crisis. Dr. Marangos draws on 45 years of experience in every aspect of the biomedical R & D field, from basic drug discovery research at the NIH to the co-founding of five drug companies. He has published 252 research papers and edited four books on drug discovery, is co-inventor on 14 patents, and founded "The Journal of Molecular Neuroscience". He argues that from a development perspective, the regulatory, patent, and legal hurdles that force industry to pursue so-called "me-too" drugs rather than cures for terminal diseases must be re-thought. Leadership accountability, strategy, focus, and urgency need to be re-evaluated, and major reforms to the NIH, FDA, and patent codes are proposed.to remedy these impediments to cures. Written for anyone frustrated with the seemingly endless threat of terminal disease, this book seeks to inform, energize, and provide the rationale for the public and industry stakeholders, as well as clinicians and researchers, to resurrect the physician-patient relationship and demand that we get serious about ridding society of this scourge on humanity.-- $c Source other than Library of Congress. 504 $a Includes bibliographical references and index. 505 0 $a Part A. The reasons for failure -- The medical R & D fiasco -- Academia is marching to the wrong drummer -- Mavericks versus the establishment -- The strangled unincentivized drug industry -- The FDA roadblock to cures -- The liability barrier -- Part B. Towards solutions -- Cleaning up the academic research quagmire -- Reforming the FDA -- Enabling the drug industry -- Patent and liability reform -- The public will make it happen. 650 0 $a Cancer $x Treatment. 650 0 $a Alzheimer's disease $x Treatment. 650 0 $a Cardiovascular system $x Treatment. $x Treatment. 650 7 $a Alzheimer's disease $x Treatment. $2 fast $0 (OCoLC)fst00806591 650 7 $a Cancer $x Treatment. $2 fast $0 (OCoLC)fst00845538 650 7 $a Cardiovascular system $x Treatment. $x Treatment. $2 fast $0 (OCoLC)fst00847218 650 2 $a Biomedical Research. 650 2 $a Drug Industry. 650 2 $a Health Policy. 650 2 $a Neoplasms $x therapy. 650 2 $a Alzheimer Disease $x therapy. 650 2 $a Cardiovascular Diseases $x therapy. 651 2 $a United States. 776 08 $i ebook version : $z 9780128127971 941 $a 1 952 $l CEAX572 $d 20200508022545.0 956 $a http://locator.silo.lib.ia.us/search.cgi?index_0=id&term_0=C5E36EEC90F111EA86A69E4897128E48 994 $a 92 $b UINInitiate Another SILO Locator Search