Includes bibliographical references (pages 271-293) and index.
Contents:
Sex differences in disease -- Evolution of the human sex chromosomes and a portrait of the human X -- X chromosome dosage compensation : an overview -- The discovery of X chromosome inactivation -- Experimental models for X inactivation studies -- Theme 1 : the initial step : creating the active and inactive X -- Theme 2 : subsequent steps : spreading and maintaining inactivation -- Variations 1 : evolution of the X inactivation center -- Variations 2 : stability of the inactive X -- Variations 3 : choice of active X -- The single active X -- Mosaicism -- Epimutations, chromatin disorders and sex differences in phenotype -- Determinants of female phenotypes.
Summary:
"This is the first book-length discussion of X inactivation, the mechanism that equalizes the expression of genes on the X chromosomes of human males and females." "Although much has been written about the Y chromosome and its role in inducing maleness, little has been written about the blueprint for female development and survival, including X inactivation. Discussions of the basis for sex differences in disease usually do not consider the sex differences in expression of X-linked genes." "Included are in-depth discussions of X inactivation, focused on the molecular mechanisms responsible for chromosome inactivation and the single active X. Also considered are the evolutionary origin of the human sex chromosomes and a genetic portrait of the human X chromosome."--Jacket.
This resource is supported by the Institute of Museum and Library Services under the provisions of the Library Services and Technology Act as administered by State Library of Iowa.