"A subject collection from Cold Spring Harbor Perspectives in biology." Includes bibliographical references and index.
Contents:
I. Chemistry and biology of proteostasis -- Physical biochemistry of protein folding and misfolding / Michele Vendruscolo, Tuomas P. J. Knowles, and Christopher M. Dobson -- Integrating protein homeostasis strategies in prokaryotes / Axel Mogk, Damon Huber, and Bernd Bukau -- Cellular strategies of protein quality control / Bryan Chen, Marco Retzlaff, Thomas Roos, and Judith Frydman -- Integration of clearance mechanisms: the proteasome and autophagy / Esther Wong and Ana Maria Cuervo -- Aging as an event of proteostasis decline / Rebecca C. Taylor and Andrew Dillin -- The stress of protein misfolding: from single cells to multicellular organisms / Tali Gidalevitz, Veena Prahlad, and Richard I. Morimoto -- II. Protein quality control in cellular compartments -- Protein folding in the cytoplasm and the heat shock response / Martin Vabulas, Swasti Raychaudhuri, Manajit Hayer-Hartl, and F. Ulrich Hartl -- Protein folding and quality control in the ER / Kazutaka Araki and Kazuhiro Nagata -- Stress and its functional link to mitochondria: role in cell survival and death / Jyoti D. Malhotra and Randy Kaufman -- Quality control of mitochondrial proteostasis / Michael J. Baker, Takashi Tatsuta, and Thomas Langer -- III. Disorders of protein homeostasis -- Hepatic fibrosis and carcinogenesis in alpha-1-antitrypsin deficiency: a prototype for chronic tissue damage in gain-of-function disorders / David H. Perlmutter and Gary A. Silverman -- Alzheimer disease / Dennis J. Selkoe -- Huntington's disease / Steven Finkbeiner -- Proteostasis and movement disorders: Parkinson's disease and amyotrophic lateral sclerosis / Daryl A. Bosco, Matthew J. LaVoie, Gregory A. Petsko, and Dagmar Ringe -- Prions / David W. Colby and Stanley B. Prusiner -- Emergent properties of proteostasis in managing cystic fibrosis / William E. Balch, Daniela Roth, and Darren M. Hutt -- Protein misfolding and retinal degeneration / Radouil Tzekov, Linda Stein, and Shalesh Kaushal -- Chemical and Biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases -- progress and prognosis / Susan L. Lindquist and Jeffery W. Kelly.
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