Part 1. Nucleic acides in oncology: prognosis, treatments screening and metastases. Circulating cell-free miR-373, miR-200a, miR-200b and miR-200c in patients with epithelial ovarian cancer -- Cell-free miRNA-141 and miRNA-205 as prostate cancer biomarkers -- Clinical utility of circulating tumor dna for molecular assessment and precision medicine in pancreatic cancer -- An enquiry concerning the characteristics of cell-free DNA released by cultured cancer cells -- Detection of p53 mutations in circulating DNA of transplanted hepatocellular carcinoma patients as a biomarker of tumor recurrence -- Unbiased detection of somatic copy number aberrations in cfDNA of lung cancer cases and high-risk controls with low coverage whole genome sequencing -- Liquid profiling in lung cancer - quantification of extracellular miRNAs in bronchial lavage -- Screening of KRAS mutation in pre- and post-surgery serum of patients suffering from colon cancer by COLD-PCR HRM -- Non-dividing cell virtosomes affect in vitro and in vivo tumour cell replication -- Features of circulating DNA fragmentation in blood of healthy females and breast cancer patients -- Liquid profiling of circulating nucleic acids as a novel tool for the management of cancer patients -- part 2. CNAPS in foetal medicine. Characterization of Human Pregnancy Specific Glycoprotein (PSG) gene copy number variations in pre-eclampsia patients -- Non-invasive prenatal diagnosis of feto-maternal platelet incompatibility by cold high resolution melting analysis -- Implementing Non-Invasive Prenatal Diagnosis (NIPD) in a National Health Service Laboratory; From Dominant to Recessive Disorders -- part 3. Biology of CNAPS. Comparative analysis of harmful physical factors effect on the cell genome -- Heterochromatic tandem repeats in the extracellular DNA -- A historical and evolutionary perspective on circulating nucleic acids and extracellular vesicles: circulating nucleic acids as homeostatic genetic entities -- Comparison of MicroRNA content in plasma and urine indicates the existence of a transrenal passage of selected MicroRNAs -- A quantitative assessment of cell-free DNA utilizing several housekeeping genes: measurements from four different cell lines -- Oligodeoxynucleotide analogues of circulating DNA inhibit dsRNA-induced immune response at the early stages of signal transduction cascade in a cell type-dependent manner -- GC-Rich DNA Fragments and oxidized cell-free DNA have different effects on NF-kB and NRF2 signaling in MSC -- Evaluation of the state of transplanted liver health by monitoring of organ-specific genomic marker in circulating DNA from receptor -- Vesicular and extra-vesicular RNAs of human blood plasma -- Artificial analogues of circulating box C/D rnas induce strong innate immune response and microRNA activation in human adenocarcinoma cells -- Multiple ways of cfDNA reception and following ROS production in endothelial cells -- Protein content of circulating nucleoprotein complexes -- part 4. Methodology. Digital PCR of genomic rearrangements for monitoring circulating tumour DNA -- mFast-SeqS as a monitoring and pre-screening tool for tumor-specific aneuploidy in plasma DNA -- Methodological variables in the analysis of cell-free DNA -- Novel technology for enrichment of biomolecules from cell-free body fluids and subsequent DNA sizing -- A rapid and sensitive method for detection of the T790M mutation of EGFR in plasma DNA -- Evaluation of different blood collection tubes and blood storage conditions for the preservation and stability of cell-free circulating DNA for the analysis of the methylated Msept9 colorectal cancer screening marker -- Purification of circulating cell-free DNA from plasma and urine using the automated large-volume extraction on the QIAsymphony SP Instrument -- Detection and quantification of KIT mutations in ctDNA by plasma Safe-SeqS -- part 5. Ethics. Lost in translation? ethical challenges of implementing a new diagnostic procedure -- Part 6. Round-table. Academia meets industry -- Index.
Series:
Advances in experimental medicine and biology, 0065-2598 ; volume 924
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