The adequate stimulus -- Pain theories -- Anatomy of nociceptors -- Molecular biology of the nociceptor/transduction -- Zoster-associated pain and nociceptors -- Ectopic generators -- Sodium channels -- Physiology of nociceptors -- Itch -- Thermal sensation (cold and heat) through thermosensitive TRP channel activation -- The development of nociceptive systems -- Appropriate/inappropriate developed "pain" paths -- Pain control: a child-centered approach -- Assaying pain-related genes: preclinical and clinical correlates -- Evolutionary aspects of pain -- Redheads and pain -- Autonomic nervous system and pain -- Sympathetic blocks for pain -- Sprouting in dorsal root ganglia -- Vagal afferent neurons and pain -- Sex, gender, and pain -- Neurotrophins and pain -- Morphological and neurochemical organization of the spinal dorsal horn -- Spinal cord physiology of nociception -- What is a wide-dynamic-range cell? -- Spinal cord mechanisms of hyperalgesia and allodynia -- Glycine receptors -- Pain following spinal cord injury -- Long-term potentiation in pain pathways -- Immune system, pain and analgesia -- Mechanisms of glial activation after nerve injury. Trigeminal mechanisms of nociception: peripheral and brainstem organization -- Migraine: a disorder involving trigeminal brainstem mechanisms -- Tooth pain -- Ascending pathways: anatomy and physiology -- Dorsal columns and visceral pain -- Visceral pain -- Irritable bowel syndrome -- Pain in childbirth -- Urothelium as a pain organ -- The brainstem and nociceptive modulation -- Emotional and behavioral significance of the pain signal and the role of the midbrain periaqueductal gray (PAG) -- The thalamus and nociceptive processing -- Psychophysics of sensations evoked by stimulation of the human central nervous system -- Nociceptive processing in the cerebral cortex -- Phantom limb pain -- Human insular recording and stimulation -- The rostral agranular insular cortex -- Descending control mechanisms -- Diffuse noxious inhibitory controls (DNIC) -- Fibromyalgia -- Pain perception: nociception during sleep. Pharmacological modulation of pain -- Forebrain opiates -- Neuropathic pain: basic mechanisms (animal) -- Animal models and neuropathic pain -- Neuropathic pain: clinical -- Neurogenic inflammation in complex regional pain syndrome (CRPS) -- Complex regional pain syndromes -- Postroke pain -- Psychophysics of pain -- Consciousness and pain -- Assessing pain in animals -- Psychological modulations of pain -- The placebo effect -- Hypnotic analgesia.
Summary:
"The International Association for the Study of Pain defines pain as "an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage." Pain in general, and pain research in particular, is especially exciting as it brings together elements of so many disciplines. This book includes a wealth of information on the molecular biology, anatomy, physiology, and biochemical bases of pain. Sixty-six chapters cover every major aspect of pain science, from molecular pathways to treatment of pain disorders. This book is unique in that it covers the breadth and depth of pain science, and it also integrates both basic and clinical aspects of pain. For scientists new to pain research, they will gain an excellent foundation of knowledge which will lead to new breakthroughs in therapies for pain." "The book presents the most scientific understanding for the neuroscience of pain, and covers pain pathways and mechanisms in both text and full color illustrations."--Jacket.
This resource is supported by the Institute of Museum and Library Services under the provisions of the Library Services and Technology Act as administered by State Library of Iowa.