Molecular Signaling Mechanisms : from Pathways to Networks, Wnt signal production, secretion, and diffusion / Madelon M. Maurice and Hendrik C.Korswagen --- Wnt Signaling transduction at the membrane / Gary Davidson and Christof Niehrs -- Wnt signal transduction in the cytoplasm : an introduction to the destruction comples / Tony W. Chen, Heather A. Wallace, Yashi Ahmed, and Ethan Lee -- An overview of gene regulation by Wnt/[beta]-catenin signaling / Chen U. Zhang and Ken M. Cadigan -- Finding a needle in genomic haystack : genome-wide approaches to identify Wnt/TCF transcriptional targets / Chandan Bhambhani and Ken M. Cadigan -- Introduction to [beta]-catenin-independent Wnt signaling pathways / Susanne Kühl and Michael Kühl -- Molecular mechanisms of Wnt pathway sepecificity / Alexandra Schambony, Guido J.R. Zaman, and Folkert Verkaar -- Modulation of Wnt signaling by endocytosis of receptor complexes / Akira Kikuchi, Shinji Matsumoto, Katsumi Fumoto, and Akira Sato -- New ingsight from proteomic analysis of Wnt signaling / Matthew P. Walker, Dennis Goldfarb, and Michael B. Major -- New insights about Wnt/[beta]-catenin pathway mechanisms from global siRAN screens / Tenzin Gocha and Ramanuj DasGupta -- Mathematical models of Wnt signaling pathways / Michael Kühl, Barbara Kracher, Alexander Gross, and Hans A. Kestler -- The Wnt's tale : on the evolution of a signaling pathway / Jenifer C. Croce and Thomas W. Holstein -- Selected key molecules in Wnt signaling. Secreted Wnt inhibitors or modulators / Paola Bovolenta, Anne-Kathrin Gorny, Pilar Esteve, and Herbert Steinbeisser -- Frizzleds as G protein-coupled receptors / Gunnar Schulte -- Dishevelled at the crossroads of pathways / Vitězslav Bryja and Ondřej Bernatík -- [Beta]-catenin : a key player in both cell adhesion and Wnt signaling / Jonathan Pettitt -- Evolutionary diversification of vertebrate TCF/LEF structure, function, and regulation / Stefan Hoppler and Marian L. Waterman -- Insights from structural analysis of protein-protein interactions by Wnt pathway components and functional multiprotein complex formation / Zhihong Cheng and Wenqing Xu -- Wnt signaling in embryonic development and adult tissue homeostasis. Wnt signaling in early vertebrate development : from fertilization to gastrulation / Eliza Zylkiewicz, Sergei Y. Sokol, and Stefan Hoppler -- Wnt/[beta]-catenin signaling in embryonic stem cells : insights into early mammalian development / Kathryn C. Davidson -- Wnt signaling in neural development / Richard I. Dorsky -- Wnt signaling in heart organogensis / Stefan Hoppler, Silvia Mazzotta, and Michael Kühl -- Wnt signaling in kidney organogenesis / Kimmo Halt and Seppo Vainio -- Wnt signaling regulation of tissue architecture (EMT and MET) and morphogenesis : consequences for colorectal and liver cancer / Theodora Fifis, Bang M. Tran, Renate H.M. Schwab, Timothy M. Johanson, Nadia Warner, Nick Barker, and Elizabeth Vincan -- Wnt signaling in adult stem cells : tissue homeostasis and regeneration / Frank J. T. Staal and Riccardo Fodde -- Restoring tissue homeostasis : Wnt signaling in tissue regeneration after acute injury / Günes Özhan and Gilbert Weidinger -- Wnt signaling in chronic disease. Wnt signaling and colorectal cancer / Kevin Myant and Owen J. Sansom -- Wnt signaling in melanoma / Jamie N. ANastas and Andy J. Chien -- Wnt signaling in mood and psychotic disorders / Stephen J. Haggarty, Karun Singh, Roy H. Perlis, and Rakesh Karmacharya -- Neuropsychiatric disease-associated genetic variation in the Wnt pathway / Stephen J. Haggarty, Karun Singh, Roy H. Perlis, and Rakesh Karmacharya -- Wnt signaling in dementia / Stephen J. Haggarty -- Therapeutic targeting of the Wnt signaling network / Felicity Rudge and Trevor Dale.
Summary:
"Widely recognized as one of the most important signaling mechanisms in development and disease, Wnt signaling pathways are networks of proteins that play significant roles in embryogenesis or cancer development. Wnt Signaling in Development and Disease addresses the fundamentals of Wnt signaling and delves into molecular pathway mechanisms, its role in embryogenesis, adult tissue homeostasis, and chronic disease. This comprehensive resource details current knowledge of Wnt signaling while looking ahead to future progress"--Provided by publisher.
This resource is supported by the Institute of Museum and Library Services under the provisions of the Library Services and Technology Act as administered by State Library of Iowa.