Introduction to molecular mechanisms in notch signal transduction and disease pathogenesis / Benedetto Daniele Giaimo, Tilman Borggrefe -- Molecular mechanisms of receptor/ligand interactions. Structural insights into notch receptor-ligand interactions / Penny A. Handford, Boguslawa Korona, Richard Suckling, Christina Redfield, Susan M. Lea -- The molecular mechanism of notch activation / Klaus N. Lovendahl, Stephen C. Blacklow, Wendy R. Gordon -- Regulation of notch function by O-glycosylation / Beth M. Harvey, Robert S. Haltiwanger -- Modeling the notch response / Udi Binshtok, David Sprinzak -- Endocytic trafficking of the notch receptor / Bj̲örn Schnute, Tobias Troost, Thomas Klein -- Intracellular signaling mechanisms. The notch interactome: complexity in signaling circuitry / Diana M. Ho, K. G. Guruharsha, Spyros Artavanis-Tsakonas -- Integration of drosophila and human genetics to understand notch signaling related diseases / Jose L. Salazar, Shinya Yamamoto -- Mechanisms of non-canonical signaling in health and disease: diversity to take therapy up a notch? / Victor Alfred, Thomas Vaccari -- The notch3 receptor and its intracellular signaling-dependent oncogenic mechanisms / Diana Bellavia, Saula Checquolo, Rocco Palermo, Isabella Screpanti -- Notch and neurogenesis / Anna Engler, Runrui Zhang, Verdon Taylor -- Notch and stem cells / Anna Bigas, Cristina Porcheri -- Oscillatory control of notch signaling in development / Ryoichiro Kageyama, Hiromi Shimojo, Akihiro Isomura -- CSL-associated corepressor and coactivator complexes / Franz Oswald, Rhett A. Kovall -- Disease links and therapeutics. Notch and senescence / Matthew Hoare, Masashi Narita -- Control of blood vessel formation by notch signaling / Fabian Tetzlaff, Andreas Fischer -- Notch and T cell function: a complex tale / Jyothi Vijayaraghavan, Barbara A. Osborne -- Notch in leukemia / Anna C. McCarter, Qing Wang, Mark Chiang.
Summary:
This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression. Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated. This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments"--Publisher's description.
Series:
Advances in experimental medicine and biology, 2214-8019 ; volume 1066
This resource is supported by the Institute of Museum and Library Services under the provisions of the Library Services and Technology Act as administered by State Library of Iowa.