Part 1. Evolution of RUNX genes. RUNX in invertebrates / S. Hughes and A. Woollard -- part 2. RUNX and CBF[Beta]: structure and function. Structure and biophysics of CBF[Beta]/RUNX and its translocation products / Tahir H. Tahirov and John Bushweller -- Covalent modifications of RUNX proteins: structure affects function / Ezra Blumenthal, Sarah Greenblatt, Guang Huang, Koji Ando, Ye Xu, and Stephen D. Nimer -- part 3. RUNX genes and mammalian development. The role of Runx1 in embryonic blood cell formation / Amanda D. Yzaguirre, Marcella F.T.R. de Bruijn, and Nancy A.Speck -- Runx1 structure and function in blood cell development / Constanze Bonifer, Elena Levantini, Valerie Kouskoff, and George Lacaud -- Roles of Runx2 in skeletal development / Toshihisa Komori -- Mitotic gene bookmarking: an epigenetic mechanism for coordination of lineage commitment, cell identity and cell growth / Sayyed K. Zaidi, Jane B. Lian, Andre van Wijnen, Janet L. Stein, and Gary S. Stein -- Roles of Runx genes in nervous system development / Jae Woong Wang and Stefano Stifani -- Runx family genes in tissue stem cell dynamics / Chelsia Qiuxia Wang, Michelle Meng Huang Mok, Tomomasa Yokomizo, Vinay Tergaonkar, and Motomi Osato -- Roles of the RUNX1 enhancer in normal hematopoiesis and leukemogenesis / Wei-Siang Liau, Phuong Cao Thi Ngoc, and Takaomi Sanda -- part 4. RUNX1 and CBF[Beta] fusion proteins in leukemia. RUNX1-ETO leukemia / Shan Lin, James C. Mulloy, and Susumu Goyanna -- Clinical relevance of RUNX1 and CBFB alterations in acute myeloid leukemia and other hematological disorders / Klaus H. Metzeler and Clara D. Bloomfield -- Mechanism of ETV6-RUNX1 leukemia / Aishwarya Sundaresh and Owen Williams ETV6-RUNX1 + acute lymphoblastic leukaemia in identical twins / Anthony M. Ford and Mel Greaves -- Molecular basis and targeted inhibition of CBF[Beta]-SMMHC acute myeloid leukemia / Lucio H. Castilla and John H. Bushweller -- part 5. RUNX and CBF[Beta] in cancer and immune function. The RUNX genes as conditional oncogenes: insights from retroviral targeting and mouse models / James C. Neil, Kathryn Gilroy, Gillian Borland, Jodie Hay, Anne Terry, and Anna Kilbey -- RUNX1 and CBF[Beta] mutations and activities of their wild-type alleles in AML / R. Katherine Hyde, Paul Liu, and Alan D. Friedman -- Roles of RUNX in B cell immortalization / Michelle J. West and Paul J. Farrell -- Roles of RUNX in solid tumors / Linda Shyue Huey Chuang, Kosei Ito, and Yoshiaki Ito -- RUNX3 and p53: how two tumor suppressors cooperate against oncogenic Ras? / Jung-Won Lee, Andre Van Wijnen, and Suk-Chul Bae -- Runx3 and cell fate decisions in pancreas cancer / Martin C. Whittle and Sunil R. Hingorani -- Runx genes in breast cancer and the mammary lineage / Nicholas Rooney, Alessandra I. Riggio, Daniel Mendoza-Villanueva, Paul Shore, Ewan R. Cameron, and Karen Blyth -- Runx3 in immunity, inflammation and cancer / Joseph Lotem, Ditsa Levanon, Varda Negreanu, Omri Bauer, Shay Hantisteanu, Joseph Dicken, and Yoram Groner -- Roles of RUNX complexes in immune cell development / Takashi Ebihara, Wooseok Seo, and Ichiro Taniuchi -- CBFß and HIV infection / Dong Young Kim, and John D. Gross -- part 6. Emergin roles for RUNX. Roles of RUNX in hippo pathway signaling / Antonino Passaniti, Jessica L. Brusgard, Yiting Qiao, Marius Sudol, and Megan Finch-Edmondson -- Roles of RUNX in hypoxia-induced responses and angiogenesis / Sun Hee Lee, Sarala Manandhar, and You Mie Lee -- The emerging roles of RUNX transcription factors in epithelial-mesenchymal transition / Dominic Chih-Cheng Voon and Jean Paul Thiery -- A regulatory role for RUNX1, RUNX3 in the maintenance of genomic integrity / Vaidehi Krishnan and Yoshiaki Ito -- Index.
Series:
Advances in experimental medicine and biology, 0065-2598 ; volume 962
This resource is supported by the Institute of Museum and Library Services under the provisions of the Library Services and Technology Act as administered by State Library of Iowa.