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Title:

Gene therapy for HIV and chronic infections / Ben Berkhout, Hildegund C.J. Ertl, Marc S. Weinberg, editors.

Publisher:

Springer ;

Copyright Date:

2015

Description:

xvi, 236 pages : illustrations (chiefly color) ; 24 cm.

Subject:

HIV infections--Gene therapy.
HIV infections--Treatment.
HIV Infections--therapy.
Genetic Therapy.

Other Authors:

Berkhout, Ben, editor.
Ertl, Hildegund C. J., editor.
Weinberg, Marc S., editor.

Notes:

Includes bibliographical references and index.

Contents:

Gene therapies for hepatitis C virus / Monique M.A. Verstegen, Qiuwei Pan, and Luc J.W. van der Laan -- Recent advances in use of gene therapy to treat hepatitis B virus infection / Kristie Bloom, Abdullah Ely, and Patrick Arbuthnot -- U1interference (U1i) for antiviral approaches / Lorea Blázquez and Puri Fortes -- Gene therapy strategies to block HIV-1 replication by RNA interference / Elena Herrera-Carrillo and Ben Berkhout -- HIV and ribozymes / Robert J. Scarborough and Anne Gatignol -- Editing CCR5: a novel approach to HIV gene therapy / Tatjana I. Cornu, Claudio Mussolino, Kristie Bloom, and Toni Cathomen -- Synthetic DNA approach to cytomegalovirus vaccine/immune therapy / Stephan J. Wu, Daniel O. Villarreal, Devon J. Shedlock, and David B. Weiner -- Vector-mediated antibody gene transfer for infectious diseases / Bruce C. Schnepp and Philip R. Johnson -- HIV latency and the non-coding RNA therapeutic landscape / Sheena Saayman, Thomas C. Roberts, Kevin V. Morris, and Marc S. Weinberg -- C peptides as entry inhibitors for gene therapy / Lisa Egerer, Hans-Peter Kiem, and Dorothee von Laer -- Aptamer-siRNA chimeras for HIV / Mayumi Takahashi, John C. Burnett, and John J. Rossi -- Index.

Summary:

This volume examines gene therapy and gene transfer approaches to preventing or treating chronic virus infections, focusing on the Big Three viral pathogens- HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV). It explores molecular antiviral strategies, including RNA interference, aptamer-siRNA chimeras, U1i interference, editing CCR5, alternative genetic vaccination by intramuscular gene transfers of virus vectors, and HIV latency in the context of non-coding RNA. This title is a volume of the American Society of Gene and Cell Therapy, a sub-series of the highly successful Advances in Experimental Medicine and Biology. In eleven illustrated chapters, leading international researchers contextualize the structure, operation, and impact of pathogens; examine the existing genetic and molecular research; and extract possible methods of preventing and treating chronic viral infections while evaluating the current body of knowledge. Authoritative and multifaceted, Gene Therapy for HIV and Chronic Infections is an ideal guide for researchers in the fields of gene therapy and immunology interested in expanding their knowledge on how to design an effective gene therapy against a viral pathogen.

Series:

Advances in Experimental Medicine and Biology, 0065-2598 ; 848

ISBN:

1493924311
9781493924318

OCLC:

(OCoLC)898157780

LCCN:

2015932964

Locations:

OVUX522 -- University of Iowa Libraries (Iowa City)