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Title:

Rational drug design : methods and protocols / edited by Yi Zheng.

Publisher:

Humana Press ;

Copyright Date:

c2012

Description:

xi, 230 p. : ill. (some col.) ; 26 cm.

Subject:

Drug Design.
Drugs--Design.
Laboratory Manuals.

Other Authors:

Zheng, Yi edt

Notes:

Includes bibliographical references and index.

Contents:

Random mutagenesis of peptide aptamers as an optimization strategy for inhibitor screening / Nathalie Bouquier ... [et al.] -- Virtual ligand screening combined with NMR to identify Dvl PDZ domain inhibitors targeting the Wnt signaling / Jufang Shan and Jie J. Zheng -- Rational design of Rho GTPase-targeting inhibitors / Xun Shang and Yi Zheng -- Rational design of peptide ligands against a glycolipid by NMR studies / Wenyong Tong ... [et al.] -- Combinatorial strategy for the acquisition of potent and specific protein tyrosine phosphatase inhibitors / Sheng Zhang ... [et al.] -- Identification of allosteric inhibitors of p21-activated kinase / Julien Viaud and Jeffrey R. Peterson -- Using a modified yeast two-hybrid system to screen for chemical GEF inhibitors / Anne Blangy and Philippe Fort -- Random mutagenesis of peptide aptamers as an optimization strategy for inhibitor screening / Nathalie Bouquier ... [et al.] --
Utilizing antagomiR (antisense microRNA) to knock down microRNA in murine bone marrow cells / Mohammad Azam -- Use of a fluorescent ATP analog to probe the allosteric conformational change in the active site of the protein kinase PDK1 / Valerie Hindie, Laura A. Lopez-Garcia, and Ricardo M. Biondi -- Affinity purification of protein kinases that adopt a specific inactive conformation / Pratistha Ranjitkar and Dustin J. Maly -- Determination of the kinetics and thermodynamics of ligand binding to a specific inactive conformation in protein kinases / Sanjay B. Hari, Pratistha Ranjitkar, and Dustin J. Maly -- Purification and specific assays for measuring APE-1 endonuclease activity / Adrian Esqueda ... [et al.] -- In vitro screening to identify drug-resistant mutations for target-directed chemotherapeutic agents / Mohammad Azam -- Utilizing antagomiR (antisense microRNA) to knock down microRNA in murine bone marrow cells /
Shengyu Yang, J. Jillian Zhang, and Xin-Yun Huang. Mouse models for tumor metastasis / Peixuan Guo ... [et al.] -- Mouse models for tumor metastasis / Shengyu Yang, J. Jillian Zhang, and Xin-Yun Huang.

Series:

Method in molecular biology, 1064-3745 ; 928
Springer protocols

ISBN:

1627030077 (alk. paper)
9781627030076 (alk. paper)

OCLC:

(OCoLC)788252989

LCCN:

2012943829

Locations:

OVUX522 -- University of Iowa Libraries (Iowa City)