1263 records matched your query       

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001 03EFCBEE621111E7BC2B04C5DAD10320
003 SILO
005 20170706010219
008 170502t20172017dcua     b    000 0 eng d
020    $a 030945249X
020    $a 9780309452496
035    $a (OCoLC)985120577
040    $a TKN $b eng $e rda $c TKN $d OCLCO $d SOI $d OCLCO $d NRC $d OCLCO $d IWA $d SILO
050  4 $a RC720 N38x 2017
110 2  $a National Academies of Sciences, Engineering, and Medicine (U.S.). $b Committee on Assessing Toxicologic Risks to Human Subjects Used in Controlled Exposure Studies of Environmental Pollutants, $e author.
245 10 $a Controlled human inhalation-exposure studies at EPA  / $c Committee on Assessing Toxicologic Risks to Human Subjects Used in Controlled Exposure Studies of Environmental Pollutants, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies ; a report of the National Academies of Sciences, Engineering, Medicine.
246 3  $a Controlled human inhalation-exposure studies at Environmental Protection Agency
264  1 $a Washington, DC : $b the National Academies Press, $c [2017]
300    $a xv, 141  pages : $b illustrations (some color) ; $c 28 cm
504    $a Includes bibliographical references (pages 95-105).
505 0  $a Introduction -- Foundational aspects of human-subjects research -- Value of controlled human inhalation exposure studies -- Assessment of controlled human inhalation exposure studies at EPA and associated adverse events -- The continued conduct of controlled human inhalation exposure studies by EPA -- Characterizing risks to subjects in controlled human inhalation exposure studies -- Communication about informed consent in controlled human inhalation exposure studies -- Reference -- Appendix A: Biographical information on the Committee on Assessing Toxicologic Risks to Human Subjects Used in Controlled Exposure Studies of Environmental Pollutants -- Appendix B: Public information-Gathering sessions -- Appendix C: Assessment of eight controlled human exposure studies.
520 1  $a "The U.S. Environmental Protection Agency (EPA) has a mission and regulatory responsibility to protect human health and the environment. EPA's pursuit of that goal includes a variety of research activities involving human subjects, such as epidemiologic studies and surveys. Those research activities also involve studies of individuals who volunteer to be exposed to air pollutants intentionally in controlled laboratory settings so that measurements can be made of transient and reversible biomarker or physiologic responses to those exposures that can indicate pathways of toxicity and mechanisms of air-pollution responses. The results of those controlled human inhalation exposure (CHIE) studies, also referred to as human clinical studies or human challenge studies, are used to inform policy decisions and help establish or revise standards to protect public health and improve air quality. Controlled Human Inhalation-Exposure Studies at EPA addresses scientific issues and provides guidance on the conduct of CHIE studies. This report assesses the utility of CHIE studies to inform and reduce uncertainties in setting air-pollution standards to protect public health and assess whether continuation of such studies is warranted. It also evaluates the potential health risks to test subjects who participated in recent studies of air pollutants at EPA's clinical research facility"--Publisher's description.
610 10 $a United States. $b Environmental Protection Agency.
650  0 $a Pulmonary toxicology.
650  0 $a Pollutants $x Health aspects.
941    $a 1
952    $l USUX851 $d 20170802025053.0
956    $a http://locator.silo.lib.ia.us/search.cgi?index_0=id&term_0=03EFCBEE621111E7BC2B04C5DAD10320