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04203aam a2200517 i 4500 001 82B322D28FC011ECBA4AA6A62FECA4DB 003 SILO 005 20220217010136 008 210606t20212021njua b 001 0 eng 010 $a 2021019815 020 $a 0691220638 020 $a 9780691220635 020 $a 0691220646 020 $a 9780691220642 035 $a (OCoLC)1246624256 040 $a LBSOR/DLC $b eng $e rda $c DLC $d OCLCO $d OCLCF $d OCLCO $d UKMGB $d TMV $d OCLCO $d YDX $d NUI $d SILO 042 $a pcc 050 00 $a QP355.2 $b .R36 2021 082 00 $a 612.8 $2 23 100 1 $a Raman, Indira, $e author. 245 14 $a The annotated Hodgkin & Huxley : $b a reader's guide / $c Indira M. Raman and David L. Ferster. 246 30 $a Annotated Hodgkin and Huxley 264 1 $a Princeton, New Jersey : $b Princeton University Press, $c [2021] 300 $a xiii, 311 pages : $b illustrations (black and white) ; $c 27 cm 520 $a "The first annotated edition of the scientific papers that created the foundation of modern neuroscience and physiology The origin of everything known about how neurons and muscles generate electrical signals can be traced back to five revolutionary papers, published in the Journal of Physiology in 1952 by Alan Hodgkin and Andrew Huxley. The principles they revealed remain cornerstones of the discipline, summarized in every introductory neuroscience and physiology course. Since that era, however, scientific practice, technology, and presentation have changed extensively. It is difficult for the modern reader to appreciate Hodgkin and Huxley's rigorous scientific thought, elegant experimental design, ingenious analysis, and beautiful writing.This book provides the first annotated edition of these papers, offering essential background on everything, from terminology, equations, and electronics, to the greater historical and scientific context surrounding the work. The original journal pages are displayed opposite detailed notes explaining content, process, and background, with copies of the figures replotted according to modern conventions. Indispensable for scientists, teachers, and trainees alike, The Annotated Hodgkin and Huxley makes an essential body of knowledge-and an unparalleled approach to research-accessible to a new generation of readers.Reproduces the original articles paired with extensive annotations on facing pages. Replots figures with modern conventions of data display. Explains the development of the voltage clamp and the discovery of ionic currents and action potential generation, foundational to the study of neuroscience and physiology. Summarizes the history of electrophysiology leading to Hodgkin and Huxley's work. Includes appendices on relevant concepts from mathematics, physics, electronics, chemical kinetics, and numerical methods"-- $c Provided by publisher. 504 $a Includes bibliographical references and index. 505 0 $a Historical background -- Paper 1 -- Paper 2 -- Paper 3 -- Paper 4 -- Paper 5. 600 10 $a Huxley, Andrew, $d 1917-2012. 600 10 $a Hodgkin, A. L. $q (Alan Lloyd) 600 17 $a Hodgkin, A. L. $q (Alan Lloyd) $2 fast $0 (OCoLC)fst00288921 600 17 $a Huxley, Andrew, $d 1917-2012. $2 fast $0 (OCoLC)fst01798529 648 7 $a 1900-1999 $2 fast 650 0 $a Neurophysiology. 650 0 $a Neurophysiology $x History $x History $y 20th century. 650 2 $a Neurophysiology $x history $0 (DNLM)D009482Q000266 650 7 $a Neurophysiology. $2 fast $0 (OCoLC)fst01036464 650 7 $a Neurophysiology $x Research. $2 fast $0 (OCoLC)fst01036472 655 7 $a History. $2 fast $0 (OCoLC)fst01411628 775 08 $i Also issued in: $t Journal of physiology $x 0022-3751 $w (OCoLC)1754742 $w (OCoLC)1754742 776 08 $i Online version: $a Raman, Indira. $t Annotated Hodgkin and Huxley $d Princeton : Princeton University Press, [2021] $z 9780691220659 $w (DLC) 2021019816 700 1 $a Ferster, David L., $e author. 700 12 $i Container of (work): $a Huxley, Andrew, $d 1917-2012. $t Works. $k Selections. 700 12 $i Container of (work): $a Hodgkin, A. L. $q (Alan Lloyd). $t Works. $k Selections. 941 $a 1 952 $l OVUX522 $d 20231117022710.0 956 $a http://locator.silo.lib.ia.us/search.cgi?index_0=id&term_0=82B322D28FC011ECBA4AA6A62FECA4DBInitiate Another SILO Locator Search