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02726aam a2200385Ii 4500 001 A7367C14E9E711E69A6025A3DAD10320 003 SILO 005 20170203020341 008 161104t20172017gw a b 001 0 eng d 020 $a 3527336583 020 $a 9783527336586 035 $a (OCoLC)962180457 040 $a OHX $b eng $e rda $c OHX $d YDX $d TKN $d OCLCF $d SILO 050 4 $a RC270.8 W34 2017 100 1 $a Wagener, C. $q (Christoph), $e author. 245 10 $a Cancer signaling : $b from molecular biology to targeted therapy / $c Christoph Wagener, Carol Stocking, and Oliver MuÂller. 264 1 $a Weinheim, Germany : $b Wiley-VCH, $c [2017] 300 $a xxix, 324 pages : $b illustrations (some color) ; $c 25 cm 500 $a Textbook. 504 $a Includes bibliographical references and index. 520 $a "Cancer, which has become the second-most prevalent health issue globally, is essentially a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow cancer to thrive - and how they can be turned into potent weapons against it - is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors provide a compelling story of how cancer works on the molecular level, and how targeted therapies using kinase inhibitors and other modulators of signaling pathways can contain and eventually cure it. The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation. The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their function in healthy versus cancer cells... "-- $c Provided by publisher. 505 0 $a General aspects of signal transduction and cancer therapy -- Tumor cell heterogeneity and resistance to targeted therapy -- Cell cycle of tumor cells -- Cell aging and cell death -- Growth factors and receptor tyrosine kinases -- The Philadelphia chromosome and BCR-ABL1 -- MAPK signaling -- PI3K-AKT-mTOR signaling -- Hypoxia-inducible factor (HIF) -- NF-kB pathways -- Wnt signaling -- Notch signaling -- Hedgehog signaling -- TGF[beta] signaling. 650 0 $a Cellular signal transduction. 650 0 $a Cancer $x Treatment. 650 0 $a Cancer cells. 650 0 $a Tumors. 650 0 $a Protein-tyrosine kinase. 650 0 $a Cancer $x Molecular aspects. 776 0 $w (GyWOH)har160536015 776 0 $w (GyWOH)har165022067 776 0 $w (GyWOH)har165022069 941 $a 1 952 $l USUX851 $d 20171003031800.0 956 $a http://locator.silo.lib.ia.us/search.cgi?index_0=id&term_0=A7367C14E9E711E69A6025A3DAD10320 994 $a C0 $b IWAInitiate Another SILO Locator Search