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04922aam a2200397 i 4500 001 F17A00F4F50B11E7A6193F6E97128E48 003 SILO 005 20180109010327 008 140203s2014 nyua b 001 0 eng d 010 $a 2013955606 020 $a 162703708X 020 $a 9781627037082 035 $a (OCoLC)870978448 040 $a UKMGB $b eng $e rda $c UKMGB $d BTCTA $d YDXCP $d DEBBG $d OCLCO $d IDL $d OCLCO $d NLGGC $d STF $d NUI $d UtOrBLW $d SILO 245 00 $a RNA sequence, structure, and function : $b computational and bioinformatic methods / $c edited by Jan Gorodkin, Walter L. Ruzzo. 264 1 $a New York : $b Humana Press, $c [2014] 300 $a xi, 533 pages : $b illustrations (some color) ; $c 27 cm. 490 1 $a Methods in molecular biology, $x 1064-3745 ; $v 1097 490 1 $a Springer protocols, $x 1949-2448 504 $a Includes bibliographical references and index. 505 0 $a Concepts and Introduction to RNA Bioinformatics -- The Principles of RNA Structure Architecture -- The Determination of RNA Folding Nearest Neighbor Parameters -- Energy Directed RNA Structure Prediction -- Introduction to Stochastic Context Free Grammars -- An Introduction to RNA Databases -- Energy-based RNA Consensus Secondary Structure Prediction in Multiple Sequence Alignments -- SCFGs in RNA Secondary Structure Prediction: A Hands-on Approach -- Annotating Functional RNAs in Genomes using Infernal -- Class-specific Prediction of ncRNAs -- Abstract Shape Analysis of RNA -- Introduction to RNA Secondary Structure Comparison -- RNA Structural Alignments, Part I: Sankoff Based Approaches for Structural Alignments -- RNA Structural Alignments, Part II: Non-Sankoff Approaches for Structural Alignments -- De novo Discovery of Structured ncRNA Motifs in Genomic Sequences., -- Phylogeny and Evolution of RNA Structure -- The Art of Editing RNA Structural Alignments -- Automated Modeling of RNA 3D Structure -- Computational Prediction of RNA-RNA Interactions -- Computational Prediction of microRNA Genes -- MicroRNA Target Finding by Comparative Genomics -- Bioinformatics of siRNA Design -- RNA-protein Interactions: An Overview. 520 $a The existence of genes for RNA molecules not coding for proteins (ncRNAs) has been recognized since the 1950's, but until recently, aside from the critically important ribosomal and transfer RNA genes, most focus has been on protein coding genes. However, a long series of striking discoveries, from RNA's ability to carry out catalytic function, to discovery of riboswitches, microRNAs and other ribo-regulators performing critical tasks in essentially all living organisms, has created a burgeoning interest in this primordial component of the biosphere. However, the structural characteristics and evolutionary constraints on RNA molecules are very different from those of proteins, necessitating development of a completely new suite of informatic tools to address these challenges. In RNA Sequence, Structure, Function: Computational and Bioinformatic Methods, expert researchers in the field describe a substantial and relevant fraction of these methodologies from both practical and computational/algorithmic perspectives. Focusing on both of these directions addresses both the biologist interested in knowing more about RNA bioinformatics as well as the bioinformaticist interested in more detailed aspects of the algorithms. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results. Thorough and intuitive, RNA Sequence, Structure, Function: Computational and Bioinformatic Methods aids scientists in continuing to study key methods and principles of RNA bioinformatics. 650 0 $a RNA. $0 http://id.loc.gov/authorities/names/no97053541 650 0 $a Nucleotide sequence. $0 http://id.loc.gov/authorities/subjects/sh85093159 650 2 $a RNA, Untranslated $x genetics. $2 [MeSH] $0 https://id.nlm.nih.gov/mesh/D022661Q000235 650 2 $a Computational Biology $x methods. $2 [MeSH] $0 https://id.nlm.nih.gov/mesh/D019295Q000379 650 2 $a Sequence Analysis, RNA $x methods. $2 [MeSH] $0 https://id.nlm.nih.gov/mesh/D017423Q000379 700 1 $a Gorodkin, Jan, $e editor. $0 http://id.loc.gov/authorities/names/nb2014010029 700 1 $a Ruzzo, Walter L., $e editor. $0 http://id.loc.gov/authorities/names/n94078710 710 2 $a Springer Science+Business Media, $e copyright holder. $0 http://id.loc.gov/authorities/names/n2005003639 773 18 $w 990001282000202771 $g no:1097 830 0 $a Methods in molecular biology (Clifton, N.J.) ; $v v. 1097. $0 http://id.loc.gov/authorities/names/n92002874 830 0 $a Springer protocols (Series). $x 1949-2448 $0 http://id.loc.gov/authorities/names/no2008180772 941 $a 1 952 $l OVUX522 $d 20180109041731.0 956 $a http://locator.silo.lib.ia.us/search.cgi?index_0=id&term_0=F17A00F4F50B11E7A6193F6E97128E48Initiate Another SILO Locator Search