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04579aam a2200385 i 4500 001 8F390856580511E8A8F83C5097128E48 003 SILO 005 20180515010114 008 170420t20172017nyua b 001 0deng d 010 $a 2017944283 020 $a 9781493971701 020 $a 1493971700 035 $a (OCoLC)983320458 040 $a YDX $b eng $e rda $c YDX $d GZM $d STF $d OCLCF $d NUI $d SILO 245 00 $a Drug safety evaluation : $b methods and protocols / $c edited by Jean-Charles Gautier. 250 $a Second edition. 264 1 $a New York, NY : $b Humana Press, $c [2017] 300 $a xi, 427 pages : $b illustrations (some color) ; $c 26 cm 490 1 $a Methods in molecular biology, $x 1064-3745 ; $v 1641 490 1 $a Springer protocols, $x 1949-2448 504 $a Includes bibliographical references and index. 505 00 $t Urine exosome isolation and characterization / $r Jonathan M. Street, Erik H. Koritzinsky, Deonna M. Glispie, and Peter S.T. Yuen. $t Juvenile nonclinical safety studies in support of pediatric drug development / $r Paul C. Barrow and Georg Schmitt -- $t Procedures of necropsy and tissue sampling / $r Laurence Fiette, Mohamed Slaoui, and Anne-Laure Bauchet -- $t Tissue sampling and processing for histopathology evaluation / $r Mohamed Slaoui, Anne-Laure Bauchet, and Laurence Fiette -- $t Principles and methods of immunohistochemistry / $r JoseÌ A. Ramos-Vara -- $t Applications of mass spectrometry imaging for safety evaluation / $r David Bonnel and Jonathan Stauber Part III Genetic Toxicology -- $t In vivo rat T-lymphocyte Pig-a assay : detection and expansion of cells deficient in the GPI-anchored CD48 surface marker for analysis of mutation in the endogenous Pig-a gene / $r Vasily N. Dobrovolsky, Javier Revollo, Dayton M. Petibone, and Robert H. Heflich -- $t Detection of in vivo mutation in the Pig-a gene of mouse bone marrow erythroids / $r Takafumi Kimoto and Daishiro Miura -- $t Use of bacterial repair endonucleases in the comet assay / $r Andrew R. Collins -- $t Automated patch-clamp methods for the hERG cardiac potassium channel / $r Sylvie Houtmann, Brigitte Schombert, Camille Sanson, Michel Partiseti, and G. Andrees Bohme -- $t Impedance measurement in induced pluripotent stem cell-derived cardiomyocytes / $r Emma-Jane Poulton -- $t Target safety assessment : strategies and resources / $r Richard J. Brennan -- $t NMR and MS methods for metabolomics / $r Alexander Amberg, BjoÌrn Riefke, GoÌtz Schlotterbeck, Alfred Ross, Hans Senn, Frank Dieterle, and Matthias Keck -- $t Protocols and applications of cellular metabolomics in safety studies using precision-cut tissue slices and carbon 13 NMR / $r Gabriel Baverel, Maha El Hage, and Guy Martin -- $t Statistical analysis of auantitative RT-PCR results / $r Richard Khan-Malek and Ying Wang -- $t Evaluation of mitochondrial respiration in cultured rat hepatocytes / $r Jean-Pierre Marchandeau and Gilles Labbe -- $t FETAX assay for evaluation of developmental toxicity / $r Isabelle Mouche, Laure MaleÌsic, and Olivier Gillardeaux -- $t Evaluation of embryotoxicity using the Zebrafish model / $r Lisa Truong and Robert L. Tanguay -- $t Absolute quantification of toxicological biomarkers via mass spectrometry / $r Thomas Y. K. Lau, Ben C. Collins, Peter Stone, Ning Tang, William M. Gallagher, and Stephen R. Pennington -- $t Next-generation sequencing to investigate urinary microRNAs from Macaca fascicularis (cynomolgus monkey) / $r Yaligara Veeranagouda, Jean-François LeÌonard, Jean-Charles Gautier, and Eric Boitier -- $t Quantitative RT-PCR for microRNAs in biofluids / $r Michael Thorsen, Thorarinn Blondal, and Peter Mouritzen -- $t Chromogenic in situ hybridization methods for microRNA biomarker monitoring of drug safety and efficacy / $r Barbara R. Gould, Tina Damgaard, and Boye Schnack Nielsen -- $t Urine exosome isolation and characterization / $r Jonathan M. Street, Erik H. Koritzinsky, Deonna M. Glispie, and Peter S.T. Yuen. 650 0 $a Drugs $x Toxicology $v Laboratory manuals. 650 0 $a Drugs $x Testing $v Laboratory manuals. 650 7 $a Drugs $x Testing. $2 fast $0 (OCoLC)fst00898940 650 7 $a Drugs $x Toxicology. $2 fast $0 (OCoLC)fst00898958 655 7 $a Laboratory manuals. $2 lcgft 655 7 $a Laboratory manuals. $2 fast $0 (OCoLC)fst01920776 700 1 $a Gautier, Jean-Charles, $e editor. 773 18 $w 990001282000202771 $g v:1641 830 0 $a Methods in molecular biology (Clifton, N.J.) ; $v v. 1641, $x 1064-3745 830 0 $a Springer protocols (Series), $x 1949-2448 941 $a 1 952 $l OVUX522 $d 20181116063920.0 956 $a http://locator.silo.lib.ia.us/search.cgi?index_0=id&term_0=8F390856580511E8A8F83C5097128E48Initiate Another SILO Locator Search