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02455aam a2200457 i 4500 001 C4E5A222586511EA978CCE3397128E48 003 SILO 005 20200226010029 008 190228t20192020flua b 001 0 eng 010 $a 2019003924 020 $a 1138490113 020 $a 9781138490116 020 $a 1439837171 020 $a 9781439837177 035 $a (OCoLC)1089277366 040 $a DLC $b eng $e rda $c DLC $d OCLCO $d OCLCF $d UKMGB $d PAU $d HMS $d OCLCO $d MUU $d WURST $d SILO 042 $a pcc 050 00 $a QH324.2 $b .A46 2019 082 00 $a 570.1/13 $2 23 100 1 $a Alon, Uri, $d 1969- $e author. 245 13 $a An introduction to systems biology : $b design principles of biological circuits / $c Uri Alon. 250 $a Second edition. 264 1 $a Boca Raton, Fla. : $b CRC Press, $c [2019] 300 $a xviii, 324 pages : $b illustrations (some color) ; $c 26 cm. 490 0 $a Mathematical and computational biology 490 0 $a Chapman & Hall/CRC mathematical and computational biology series 504 $a Includes bibliographical references and index. 505 0 $a Part 1. Network motifs -- Transcription networks : basic concepts -- Autoregulation : a network motif -- The feed forward loop network motif -- Temporal programs and the global structure of transcription networks -- Positive feedback, bistability and memory -- How to build a biological oscillator -- Part 2. Robustness -- Kinetic proofreading and conformational proofreading -- Robust signalling by bifunctional componets -- Robustness in bacterial chemotaxis -- Fold-change detection -- Dynamical compensation and mutal resistance in tissues -- Robust spatial patterning in development -- Part 3. Optimality -- Optimal gene circuit design -- Multi-objective optimality in biology -- Modularity. 650 0 $a Systems biology. 650 0 $a Computational biology. 650 0 $a Biological systems $x Mathematical models. 650 12 $a Gene Regulatory Networks. $0 (DNLM)D053263 650 12 $a Systems Biology $x methods. $0 (DNLM)D049490Q000379 650 7 $a Biological systems $x Mathematical models. $2 fast $0 (OCoLC)fst00832340 650 7 $a Computational biology. $2 fast $0 (OCoLC)fst00871990 650 7 $a Systems biology. $2 fast $0 (OCoLC)fst01745552 776 08 $i ebook version : $z 9781000008166 941 $a 2 952 $l USUX851 $d 20240717030843.0 952 $l OVUX522 $d 20220317025640.0 956 $a http://locator.silo.lib.ia.us/search.cgi?index_0=id&term_0=C4E5A222586511EA978CCE3397128E48Initiate Another SILO Locator Search