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03197aam a22003978i 4500 001 56DA6BD4CD6211EE9507C16149ECA4DB 003 SILO 005 20240217010049 008 230402s2024 fluab b 001 0 eng 010 $a 2023014141 020 $a 1032411856 020 $a 9781032411859 020 $a 1032412283 020 $a 9781032412283 035 $a (OCoLC)1388495816 040 $a DLC $b eng $e rda $c DLC $d OCLCF $d OCLCO $d NUI $d SILO 042 $a pcc 050 00 $a QH324.2 $b .A467 2024 082 00 $a 570.285 $2 23/eng/20230630 100 1 $a Alon, Uri, $d 1969- $e author. 245 10 $a Systems medicine : $b physiological circuits and the dynamics of disease / $c Uri Alon. 263 $a 2308 264 1 $a Boca Raton : $b CRC Press, $c 2024. 300 $a 255 pages : $b illustrations, charts ; $c 27 cm 520 $a "Systems Medicine: Physiological Circuits and the Dynamics of Disease introduces the topic of physiological circuits, in which cells and organs communicate with each other. Rather than circuits inside a cell, it discusses circuits between cells. This is the level relevant to the most common and deadly diseases that currently plague humanity. The goal is to start from basic principles or 'laws' and derive why physiology is built the way it is, and why certain diseases happen while others don't. By the end of the book, you will be able to use simple but powerful mathematical models to describe physiological circuits. The models are powerful because they turn details into useful understanding and new ways to think about treating diseases. We will understand the fundamental causes of some of the most mysterious diseases: diabetes, autoimmune diseases, and age-related diseases such as lung fibrosis and cancer. The trajectory begins with basic principles. From these are derived circuits and their fragility to disease. The book explores (i) hormone circuits, (ii) immune circuits, and (iii) aging and age-related disease, and culminates in a periodic table of diseases. It is written in a very accessible style, suitable for anyone with a background in biology, engineering, physics, math, engineering, computer science, chemistry, or other subjects"-- $c Provided by publisher. 504 $a Includes bibliographical references and index. 505 0 $a The insulin-glucose circuit -- Dynamical compensation, mutant resistance, and type-2 diabetes -- The stress hormone axis as a two-gland oscillator -- Autoimmune diseases as a fragility of mutant surveillance -- Inflammation and fibrosis as a bistable system -- Basic facts of aging -- Aging and saturated repair -- Age-related diseases -- Periodic table of diseases -- Epilogue: Simplicity in systems medicine. 650 0 $a Biological systems $x Mathematical models. 650 0 $a Human physiology $x Mathematical models. 650 0 $a Systems biology. 650 7 $a Biological systems $x Mathematical models $2 fast $0 (OCoLC)fst00832340 650 7 $a Human physiology $x Mathematical models $2 fast $0 (OCoLC)fst00963191 650 7 $a Systems biology $2 fast $0 (OCoLC)fst01745552 941 $a 1 952 $l OVUX522 $d 20240217011724.0 956 $a http://locator.silo.lib.ia.us/search.cgi?index_0=id&term_0=56DA6BD4CD6211EE9507C16149ECA4DBInitiate Another SILO Locator Search