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04423aam a2200337Ki 4500 001 D61A575E471C11EA8C4E586797128E48 003 SILO 005 20200204010450 008 180122s2018 enka b 001 0 eng d 020 $a 0128099127 020 $a 9780128099124 035 $a (OCoLC)1020027174 040 $a YDX $b eng $e rda $c YDX $d BDX $d UKMGB $d OCLCO $d OCLCF $d OCLCQ $d YDXIT $d OCLCO $d OCLCA $d SILO 050 4 $a QR188.3 E65 2018 245 04 $a The epigenetics of autoimmunity / $c edited by Rongxin Zhang, Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China. 264 1 $a London : $b Academic Press, an imprint of Elsevier, $c [2018] 300 $a xix, 411 pages ; $c 24 cm. 490 1 $a Translational epigenetics ; $v 5 504 $a Includes bibliographical references and index. 505 0 $a 1. The epigenetics of autoimmunity: an overview -- 2. Immune cell development and epigenetics -- 3. DNA methylation and histone modifications in autoimmunity -- 4. MicroRNA and T helper cell-mediated immune responses -- 5. Long noncoding RNAs in the immune response -- 6. Epigenetics of systemic lupus erythematosus -- 7. Rheumatoid arthritis and epigenetics -- 8. Epigenetic modifications in multiple sclerosis pathophysiology: potential diagnostic and therapeutic applications -- 9. Type 1 diabetes and epigenetics -- 10. Systemic sclerosis and epigenetics -- 11. Primary Sjogren's syndrome and epigenetics -- 12. Autoimmune thyroid diseases and epigenetics -- 13. The epigenetics of primary biliary cholangitis -- 14. Immune-mediated pulmonary disease and epigenetics -- 15. The epigenetics of autoimmunity and epigenetic drug discovery -- 16. Treatment of autoimmune diseases and prevention of transplant rejection and graft-versus-host disease by regulatory T cells: the state of the art and perspectives -- 17. Noncoding RNA-targeted therapeutics in autoimmune diseases: from bench to bedside -- 18. Future challenges and prospects for the epigenetics of autoimmunity -- Index. 520 $a The Epigenetics of Autoimmunity covers a topic directly related to translational epigenetics. Via epigenetic mechanisms, a number of internal and external environmental risk factors, including smoking, nutrition, viral infection and the exposure to chemicals, could exert their influence on the pathogenesis of autoimmune diseases. Such factors could impact the epigenetic mechanisms, which, in turn, build relationship with the regulation of gene expression, and eventually triggering immunologic events that result in instability of immune system. Since epigenetic aberrations are known to play a key role in a long list of human diseases, the translational significance of autoimmunity epigenetics is very high. To bridge the gap between environmental and genetic factors, over the past few years, great progress has been made in identifying detailed epigenetic mechanisms for autoimmune diseases. Furthermore, with rapid advances in technological development, high-throughput screening approaches and other novel technologies support the systematic investigations and facilitate the epigenetic identification. This book covers autoimmunity epigenetics from a disease-oriented perspective and several chapters are presented that provide advances in wide-spread disorders or diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes (T1DM), systemic sclerosis (SSc), primary SjiÌA̽gren's syndrome (pSS) and autoimmune thyroid diseases (AITDs). These emerging epigenetic studies provide new insights into autoimmune diseases, raising great expectations among researchers and clinicians. This seminal book on this topic comprehensively covers the most recent advances in this exciting and rapidly developing new science. They might reveal not only new clinical biomarkers for diagnosis and disease progression, but also novel targets for potential epigenetic therapeutic treatment. 650 0 $a Autoimmunity $x Molecular aspects. 650 0 $a Autoimmune diseases $x Etiology. 650 0 $a Epigenesis. 700 1 $a Zhang, Rongxin, $e editor. 776 08 $i Ebook version : $z 9780128099285 830 0 $a Translational epigenetics series; $v volume 5. 941 $a 1 952 $l USUX851 $d 20200402014302.0 956 $a http://locator.silo.lib.ia.us/search.cgi?index_0=id&term_0=D61A575E471C11EA8C4E586797128E48 994 $a C0 $b IWAInitiate Another SILO Locator Search