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04431aam a2200409 a 4500 001 3E5B37AE517511E0A5987EABC41A358D 003 SILO 005 20110318103249 008 101105s2011 nyua b 001 0 eng d 010 $a 2010937423 020 $a 1603271864 (alk. paper) 020 $a 9781603271868 (alk. paper) 035 $a (OCoLC)678514802 040 $a HNC $c HNC $d SILO $d COU $d IXA $d SILO 050 14 $a QH506 $b .M45 v.691 245 0 $a Drug safety evaluation : $b methods and protocols / $c edited by Jean-Charles Gautier. 260 $a New York, NY : $b Humana Press, $c c2011. 300 $a xiii, 431 p. : $b ill. (some col.) ; $c 26 cm. 490 1 $a Methods in molecular biology, $x 1064-3745 ; $v 691 490 1 $a Spinger protocols 504 $a Includes bibliographical references and index. 505 0 $a General toxicology. Developing combination drugs in preclinical studies / Alberto Lodola -- Preclinical evaluation of juvenile toxicity / Paul C. Barrow, SteÌphane Barbellion, and Jeanne Stadler -- Pathology. Necropsy and sampling procedures in rodents / Laurence Fiette and Mohamed Slaoui -- Histopathology procedures : from tissue sampling to histopathological evaluation / Mohamed Slaoui and Laurence Fiette -- Principles and methods of immunohistochemistry / JoseÌ A. Ramos-Vara -- Tissue microarrays and digital image analysis / Denise Ryan ... [et al.] -- Genetic toxicology. Micronucleus assay and labeling of centromeres with FISH technique / Ilse Decordier, Raluca Mateuca, and Micheline Kirsch-Volders -- The use of bacterial repair endonucleases in the comet assay / Andrew R. Collins -- 505 8 $a Safety pharmacology. Manual whole-cell patch-clamping of the HERG cardiac K⺠channel / Xiao-Liang Chen, Jiesheng Kang, and David Rampe -- Investigative toxicology. Generation and analysis of transcriptomics data / Philip D. Glaves and Jonathan D. Tugwood -- Protocols of two-dimensional difference gel electrophoresis to investigate mechanisms of toxicity / Emmanuelle Com ... [et al.] -- Protocols and applications of cellular metabolomics in safety studies using precision-cut tissue slices and carbon 13 NMR / Gabriel Baverel ... [et al.] -- Statistical analysis of quantitative RT-PCR results / Richard Khan-Malek and Ying Wang -- Evaluation of mitochondrial respiration in cultured rat hepatocytes / Jean-Pierre Marchandeau and Gilles Labbe -- 505 8 $a Screening assays for developmental toxicity. FETAX assay for evaluation of developmental toxicity / Isabelle Mouche, Laure Malesic, and Olivier Gillardeaux -- Evaluation of embryotoxicity using the zebrafish model / Lisa Truong, Stacey L. Harper, and Robert L. Tanguay -- 505 8 $a Chemical protein adducts. Protocols of in vitro protein covalent binding studies in liver / Jean-François LeÌvesque, Stephen H. Day, and Allen N. Jones -- Utilization of MALDI-TOF to determine chemical-protein adduct formation in vitro / Ashley A. Fisher ... [et al.] -- Utilization of LC-MS/MS analyses to identify site-specific chemical protein adducts in vitro / Ashley A. Fisher ... [et al.] -- One-dimensional western blotting coupled to LC-MS/MS analysis to identify chemical-adducted proteins in rat urine / Matthew T. Labenski ... [et al.] -- Identification of chemical-adducted proteins in urine by multi-dimensional protein identification technology (LC/LC-MS/MS) / Matthew T. Labenski ... [et al.] -- 505 8 $a Safety biomarkers. Optimization of SELDI for biomarker detection in plasma / Jean-Francois LeÌonard, Martine Courcol, and Jean-Charles Gautier -- Differential proteomics incorporating iTRAQ labeling and multi-dimensional separations / Ben C. Collins ... [et al.] -- NMR and MS methods for metabonomics / Frank Dieterle ... [et al.] -- Absolute quantification of toxicological biomarkers by multiple reaction monitoring / Thomas Y. K. Lau ... [et al.]. 650 0 $a Drugs $x Toxicology. 650 0 $a Drugs $x Testing. 650 12 $a Drug Evaluation, Preclinical $x methods $v Laboratory Manuals. $2 [MeSH] 650 22 $a Drug Evaluation $x methods $v Laboratory Manuals. $2 [MeSH] 650 22 $a Pharmacokinetics $v Laboratory Manuals. $2 [MeSH] 700 1 $a Gautier, Jean-Charles. 830 0 $a Methods in molecular biology (Clifton, N.J.) ; $v 691. 830 0 $a Springer protocols. 941 $a 1 952 $l OVUX522 $d 20171222053305.0 956 $a http://locator.silo.lib.ia.us/search.cgi?index_0=id&term_0=3E5B37AE517511E0A5987EABC41A358DInitiate Another SILO Locator Search