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03096aam a2200349Ii 4500 001 220AD7C678F611ECAF30597D2FECA4DB 003 SILO 005 20220119010213 008 160125s2015 xxua 001 0 eng d 020 $a 1512360295 020 $a 9781512360295 035 $a (OCoLC)935942346 040 $a OOJ $b eng $e rda $c OOJ $d OOJ $d OCLCQ $d PWT $d OCLCO $d OCLCF $d OCLCA $d JDP $d OCLCO $d OCLCA $d SILO 050 14 $a QR46 $b .V377 2015 060 4 $a QW 4 V335h 2015 100 1 $a Vasquez, Alex. 245 10 $a Human microbiome and dysbiosis in clinical disease : $b an integrative functional medicine approach to understanding and treating microbial imbalances and chronic infections / $c Alex Vasquez. 264 2 $a [United States?] : $b International College of Human Nutrition & Functional Medicine, $c [2015] 300 $a xiv, 144, 118 pages : $b illustrations ; $c 28 cm 500 $a Peer-reviewed monograph for continuing education program. Volume 1: parts 1-4 - cover. 505 0 $a Section 1: Infections & dysbiosis: subclinical infections & persistent microbial colonization. 1. Molecules from microbes that promote disease (and health) -- Gram-negative bacterial products, LPS -- Gram-positive bacterial products -- L-form, pleomorphic, "cell wall-deficient" bacteria -- Immunostimulation by bacterial DNA, viral DNA -- Superantigens -- Antimetabolites -- Beneficial metabolites and molecular signatures -- 2. Mechanisms of dysbiosis/colonization in clinical disease -- Damage to the intestinal mucosa -- Activation of inflammatory pathways -- TLR, NFkB, DAMP/PAMP -- Mitochondrial hyperpolarization, mTOR activation -- Molecular mimicry, cross-reactivity -- Enhanced presentation of autoantigens -- Bystander activation -- Haptenization and the formation of neoautoantigens -- Immune complex formation and disposition -- Insufficiency dysbiosis -- Microbial allergy, hypersensitivity -- Inhibition of detoxification -- Bacterial and fungal proteases impair immune defenses -- Immunosuppression via gliotoxins -- Mold toxins -- mycotoxins -- Biofilms -- Impairment of mucosal digestion -- Central sensitization, microbiome-gut-brain axis -- Dysbiosis-induced endocrine dysfunction -- Microbe-induced epigenetic changes -- Altered vitamin D metabolism and reception -- 3. Prototypic microbe-disease clinical presentations -- Autointoxication, auto-brewery syndrome, encephalopathy -- Syndromes of pain, fatigue, depression -- Dysbiotic arthropathy, dermatitis, vasculitis -- Reactive arthritis -- 4. Locations of dysbiosis, introduction to the viral microbiome -- Review questions -- Index to text section -- Section 2. Presentation slides and diagrams. 650 0 $a Medical microbiology. 650 0 $a Infection. 650 7 $a Infection. $2 fast $0 (OCoLC)fst00972325 650 7 $a Medical microbiology. $2 fast $0 (OCoLC)fst01014362 650 2 $a Microbiota. 650 2 $a Dysbiosis $x therapy. 650 2 $a Anti-Infective Agents. 941 $a 1 952 $l LVOX826 $d 20220318014225.0 956 $a http://locator.silo.lib.ia.us/search.cgi?index_0=id&term_0=220AD7C678F611ECAF30597D2FECA4DB 994 $a 92 $b PWTInitiate Another SILO Locator Search