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03227aam a2200385Ii 4500 001 B137868A6BEF11E5917E58C1DAD10320 003 SILO 005 20151006010103 008 150220t20152015sz a b 001 0 eng d 020 $a 3319165364 020 $a 9783319165363 035 $a (OCoLC)903763319 040 $a YDXCP $b eng $e rda $c YDXCP $d OCLCQ $d BTCTA $d MMU $d IaU $d SILO 050 4 $a QH588.S83 060 4 $a WL 358 082 04 $a 616.02774 $2 23 245 00 $a Stem cell biology in neoplasms of the central nervous system / $c Moneeb Ehtesham, editor. 264 1 $a Cham, Switzerland ; $b Springer, $c [2015] 300 $a xiii, 190 pages : $b color illustrations ; $c 24 cm. 490 1 $a Advances in experimental medicine and biology, $x 0065-2598 ; $v 853 504 $a Includes bibliographical references and index. 505 0 $a Regulation of subventricular zone-derived cells migration in the adult brain -- The SVZ and its relationship to stem cell based neuro-oncogenesis -- Isolation and characterization of stem cells from human central nervous system malignancies -- The role of stem cells in pediatric central nervous system malignancies -- Laboratory models for central nervous system tumor stem cell research -- Radiation therapy for glioma stem cells -- Chemoresistance and chemotherapy targeting stem-like cells in malignant glioma -- Immunobiology and immunotherapeutic targeting of glioma stem cells -- Emerging strategies for the treatment of tumor stem cells in central nervous system malignancies. 520 $a "This volume presents the most current reviews on how cancer stem cells (CSCs) hypothesis dictates that the continued proliferation of a tumor is dependent on a sub-population of self-renewing and asymmetrically dividing neoplastic stem cells that supply a largely differentiated tumor. This volume provides a comprehensive overview of the characteristics of CSCs, their role in central nervous system (CNS) tumors, and the recent CSC-specific treatment modalities being used. The emerging focus on CSCs in brain tumors represents a paradigm shift in our understanding of the pathogenesis of these neoplasms. Importantly, the realization that a distinct sub-population of cells contributes disproportionately to the growth and sustenance of central nervous system tumors has important implications for the treatment of such tumors. To treat CNS tumors, there is now a growing need to treat CSCs to achieve adequate tumor control"--Publisher's description. 650 0 $a Stem cells. 650 0 $a Central nervous system $x Tumors. 650 12 $a Central Nervous System Neoplasms $x physiopathology. $2 [MeSH] 650 12 $a Neoplastic Stem Cells $x physiology. $2 [MeSH] 650 22 $a Anti-Neoplastic Agents $x therapeutic use. $2 [MeSH] 650 22 $a Central Nervous System Neoplasms $x therapy. $2 [MeSH] 700 1 $a Ehtesham, Moneeb, $e editor. 776 08 $i Online version: $t Stem cell biology in neoplasms of the central nervous system. $d Cham : Springer, [2015] $z 9783319165370 $w (OCoLC)908030555 830 0 $a Advances in experimental medicine and biology ; $v v. 853. 941 $a 1 952 $l OVUX522 $d 20180112013745.0 956 $a http://locator.silo.lib.ia.us/search.cgi?index_0=id&term_0=B137868A6BEF11E5917E58C1DAD10320Initiate Another SILO Locator Search