Part I: Basic components. Systems hematology: an introduction / Seth Joel Corey, Marek Kimmel and Joshua N. Leonard -- Quantification and modeling of stem cell-niche interaction / Axel Krinner and Ingo Roeder -- Erythropoiesis: from molecular pathways to system properties / Miroslav Koulnis, Ermelinda Porpiglia, Daniel Hidalgo and Merav Socolovsky -- Systems biology of megakaryocytes / Alexis Kaushansky and Kenneth Kaushansky -- Systems biology of platelet-vessel wall interactions / Yolande Chen, Seth Joel Corey, Oleg V. Kim and Mark S. Alber -- Systems approach to phagoycte production and activation: neutrophils and monocytes / Hrishikesh M. Mehta, Taly Glaubach and Seth Joel Corey -- part II. Physiological processes. Stochasticity and determinism in models of hematopoiesis / Marek Kimmel -- Systems analysis of high-throughput data / Rosemary Braun -- Developing a systems-based understanding of hematopoietic stem cell cycle control / Ka Tat Siu and Alex C. Minella -- A systems biology approach to iron metabolism / Julia Chifman, Reinhard Laubenbacher and Suzy V. Torti -- Innate immunity in disease: insights from mathematical modeling and analysis / Nabil Azhar and Yoram Vodovotz -- Modeling biomolecular site dynamics in immunoreceptor signaling systems / Lily A. Chylek, Bridget S.Wilson and William S. Hlavacek -- Structure and function of platelet receptors initiating blood clotting / Elizabeth E. Gardiner and Robert K. Andrews -- Part III: Clinical applications / -- Understanding and treating cytopenia through mathematical modeling / Jinzhi Lei and Michael C. Mackey -- Drug resistance / Cristian Tomasetti -- Etiology and treatment of hematological neoplasms: stochastic mathematical models / Tomas Radivoyevitch, Huamin Li and Rainer K. Sachs -- Assessing hematopoietic (stem-) cell behavior during regenerative pressure / Thomas Stiehl, Anthony D. Ho and Anna Marciniak-Czochra -- Engineered cell-based therapies: a vanguard of design-driven medicine / Rachel M. Dudek, Yishan Chuang and Joshua N. Leonard -- Part IV: Epilogue. A systems approach to blood disorders / Pankaj Qasba -- Index.
Series:
Advances in experimental medicine and biology, 0065-2598 ; volume 844
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