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03017aam a2200457 a 4500 001 E65CFB82F83411E784964A6B97128E48 003 SILO 005 20180113013733 008 101013t20122012njua b 001 0 eng 010 $a 2010043475 020 $a 1118016424 020 $a 9781118016428 020 $a 1118016416 020 $a 9781118016411 020 $a 1118016432 020 $a 9781118016435 020 $a 0470261234 020 $a 9780470261231 035 $a (OCoLC)671465383 040 $a DNLM/DLC $e rda $c DLC $d YDX $d NLM $d YDXCP $d CDX $d VRC $d UtOrBLW $d SILO 042 $a pcc 050 00 $a RM301.25 $b .S97 2012 245 00 $a Systems biology in drug discovery and development / $c edited by Daniel L. Young, Seth Michelson. 264 1 $a Hoboken, New Jersey : $b Wiley, $c [2012] 300 $a xvii, 370 pages : $b illustrations (some color) ; $c 25 cm. 490 1 $a Wiley series on technologies for the pharmaceutical industry 504 $a Includes bibliographical references and index. 505 0 $a Introduction to systems biology in drug discovery and development -- Methods for in silico biology : model construction and analysis -- Methods in in silico biology : modeling feedback dynamics in pathways -- Simulation of population variability in pharmacokinetics -- Applications of systems biology approaches to target identification and validation in drug discovery -- Lead identification and optimization -- The role of core biological motifs in dose-response modeling : an example with switch-like circuits -- Mechanism based pharmacokinetic-pharmacodynamic modeling during discovery and early development -- Developing oncology drugs using virtual patients of vascular tumor diseases -- Systems modeling applied to candidate biomarker identification -- Simulating clinical trials -- Pathway analysis in drug discovery -- Functional mapping for predicting drug response and enabling personalized medicine -- Future outlook of systems biology. 650 0 $a Drug development. $0 http://id.loc.gov/authorities/subjects/sh97007921 650 0 $a Systems biology. $0 http://id.loc.gov/authorities/subjects/sh2008002926 650 12 $a Drug Discovery $x methods. $2 [MeSH] $0 https://id.nlm.nih.gov/mesh/D055808Q000379 650 22 $a Models, Biological. $2 [MeSH] $0 https://id.nlm.nih.gov/mesh/D008954 650 22 $a Pharmacokinetics. $2 [MeSH] $0 https://id.nlm.nih.gov/mesh/D010599 650 22 $a Pharmacological Phenomena. $2 [MeSH] $0 https://id.nlm.nih.gov/mesh/D000069437 650 22 $a Systems Biology $x methods. $2 [MeSH] $0 https://id.nlm.nih.gov/mesh/D049490Q000379 700 1 $a Young, Daniel L., $e editor. $0 http://id.loc.gov/authorities/names/n2010184170 700 1 $a Michelson, Seth, $e editor. $0 http://id.loc.gov/authorities/names/n79020127 830 0 $a Wiley series on technologies for the pharmaceutical industry. $0 http://id.loc.gov/authorities/names/n2006185394 941 $a 1 952 $l OVUX522 $d 20231019020605.0 956 $a http://locator.silo.lib.ia.us/search.cgi?index_0=id&term_0=E65CFB82F83411E784964A6B97128E48Initiate Another SILO Locator Search