7 records matched your query       

Author:

Bates, Andrew D.

Title:

DNA topology / Andrew D. Bates, Anthony Maxwell.

Publisher:

IRL Press at Oxford University Press,

Copyright Date:

c1993

Description:

xii, 114 p. : ill. (some col.) ; 23 cm.

Subject:

DNA--Conformation.
DNA--ultrastructure

Other Authors:

Maxwell, Anthony.

Notes:

Erratum slip inserted. Includes bibliographical references and index.

Contents:

DNA structure -- Watson-Crick model -- B-form DNA -- A-form DNA -- Z-form DNA -- Alternative DNA structures -- Cruciforms and Holliday junctions -- H-DNA -- Intrinsic curvature and DNA bending -- Intrinsic curvature -- DNA flexibility -- DNA supercoiling -- Historical perspective -- Closed-circular DNA and supercoiling -- Quantitative measure of DNA supercoiling -- Linking number -- Supercoiling, linking difference, and specific linking difference -- Geometric properties of closed-circular DNA -- Twist and writhe -- Interconversion of twist and writhe -- Nomenclature -- Topology and geometry of real DNA -- Agarose gel electrophoresis of plasmids -- Relaxation with topoisomerases -- Effect of intercalators -- Effect of protein binding -- Thermodynamics of DNA supercoiling -- Ethidium bromide titration -- Gaussian distribution of topoisomers -- Effect of DNA circle size -- Supercoiling in small DNA circles -- Biological effects of supercoiling free energy -- DNA on surfaces -- Helical repeat of DNA -- Surface linking treatment -- DNA winding number -- Surface linking number -- Interwound supercoiled DNA.
(cont) Nucleosome -- Linking difference and the linking number paradox -- Early resolution of the linking number paradox -- Helical repeat at the nucleosome surface -- Measurements of hs for the nucleosome -- Topology and geometry of DNA in the nucleosome -- Knots and catenanes -- Knots -- Occcurrence of knots -- Description of knots -- Catenanes -- Occurrence of catenanes -- Description of catenanes -- Knots and catenanes as probes of DNA: protein interactions -- DNA topoisomerases -- Reactions of topoisomerases -- Mechanisms of topoisomerases -- Topoisomerases as drug targets -- Biological role of topoisomerases -- Biological consequences of DNA topology -- Introduction: the ubiquity of DNA supercoiling -- General biological consequences of negative supercoiling -- Genome organization -- Eukaryotes -- Prokaryotes -- Transcription: the twin supercoiled domain model -- New role for topoisomerases -- Control of gene expression -- RNA polymerase binding -- Transcriptional regulatory proteins -- Replication -- Replication initiation -- Replication elongation -- Termination of replication.
(cont) Recombination -- Bacteriophage c Int protein -- Resolvase.

Series:

In focus

ISBN:

9780199633494
0199633495 (pbk.) :

OCLC:

(OCoLC)26308746

LCCN:

92027979

Locations:

USUX851 -- Iowa State University - Parks Library (Ames)