An insuperable problem -- Nature's solutions : the DNA topoisomerases -- Breaking a DNA strand and holding onto the broken ends -- A magic swivel -- Moving one DNA double helix through another -- Real time viewing of the DNA topoisomerases in action -- Manifestations of DNA entanglement : replication and recombination -- Manifestations of DNA entanglement : gene expression -- Beyond DNA untanglement: new twists on an old theme -- From nature's battlefields to the clinical wards -- Appendix 1: Identification of the covalent intermediates in topoisomerase catalyzed reactions -- Appendix 2: Catalysis of DNA breakage and rejoining by DNA topoisomerases.
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