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01832aam a2200349 a 4500 001 148E6C5CC6D811DFAADC769E6AFF544E 003 SILO 005 20100923010146 008 090714s2011 paua 001 0 eng 010 $a 2009028928 020 $a 0781750091 020 $a 9780781750097 035 $a (OCoLC)426115435 040 $a DNLM/DLC $c DLC $d SILO $d BAKER $d YDXCP $d NLM $d C#P $d SILO 042 $a pcc 100 1 $a Rowland, Malcolm. 245 1 $a Clinical pharmacokinetics and pharmacodynamics : $b concepts and applications / $c Malcolm Rowland, Thomas N. Tozer. 250 $a 4th ed. 260 $a Philadelphia : $b Wolters Kluwer Health/Lippincott William & Wilkins, $c c2011. 300 $a xxii, 839 p. : $b ill. ; $c 26 cm. 500 $a Rev. ed. of: Clinical pharmacokinetics. 1995. 500 $a Includes index. 505 0 $a Therapeutic relevance -- Fundamental concepts and terminology -- Kinetics following an intravenous bolus dose -- Membranes and distribution -- Elimination -- Kinetics following an extravascular dose -- Absorption -- Response following a single dose -- Therapeutic window -- Constant-rate input -- Multiple-dose regimens -- Variability -- Genetics -- Age, weight, and gender -- Disease -- Nonlinearities -- Drug interactions -- Initiating and managing therapy -- Distribution kinetics -- Metabolites and drug response -- Protein drugs -- Prediction and refinement of human kinetics from in vitro, preclinical, and early clinical data. 650 0 $a Pharmacokinetics. 650 0 $a Chemotherapy. 650 12 $a Pharmacokinetics. 650 22 $a Drug Therapy. 700 1 $a Tozer, Thomas N. 700 1 $a Rowland, Malcolm. $t Clinical pharmacokinetics. 941 $a 1 952 $l OVUX522 $d 20180118031131.0 956 $a http://locator.silo.lib.ia.us/search.cgi?index_0=id&term_0=148E6C5CC6D811DFAADC769E6AFF544EInitiate Another SILO Locator Search