1. The Basics -- 2. Implicit Experiments and the Functional Gene -- 3. Recombination and Linkage Mapping -- 4. Pathway Analysis -- 5. Regulation of Metabolic Pathways -- 6. Phage and the Beginning of Molecular Genetics -- 7. Transcription, Translation and the Genetic Code -- 8. Suppression Genetics -- 9. Functional Suppression -- 10. Genetics of Complex Phenotypes -- 11. Transcriptional Regulation of Gene Expression -- 12. The Modular Regulatory Architecture of Genes and Genomes -- 13. Evolution Conserves Functional Sequences -- 14. Human Population Genetics.
Summary:
"In this book, the distinguished geneticist David Botstein offers help and advice to scientists and physicians daunted by the arcane technical terms that flourish in his discipline. As knowledge of gene function has progressed over the past century, it has acquired a vocabulary of specialized, sometimes confusing, terms to explain some of its fundamental principles; how traits and diseases are inherited; how genes are organized and regulated in the genome; and how the genetic code is read and translated by cells. These terms often prevent the less expert from fully understanding the concepts that underlie the power of genetic studies. This is not just a theoretical handicap. As more and more individuals learn about their genomes, the information these sequences contain cannot be understood or explained without reference to the basic ideas of genetics. Botstein draws on his long experience as a teacher and pioneering scientist to explain and illuminate what many genetic terms mean and how they entered common usage. To colleagues in the field, his message is one of encouragement, to "make our work more generally accessible by modernizing, clarifying, and simplifying the language we use and teach.""-- Provided by publisher. "This is a book about the conceptual language of genetics. There is a need for special words and terms to deal with some of the essential abstractions in genetics; these are the focus of this book. It is intended to help readers with diverse interests and experience to think about genetic analysis in a more sophisticated and creative way"-- Provided by publisher.
This resource is supported by the Institute of Museum and Library Services under the provisions of the Library Services and Technology Act as administered by State Library of Iowa.