Mary Sutter is a brilliant, headstrong midwife from Albany, New York, who dreams of becoming a surgeon. Determined to overcome the prejudices against women in medicine and eager to run away from her recent heartbreak, Mary leaves home and travels to Washington, D.C. to help tend the legions of Civil War wounded. Under the guidance of surgeons William Stipp and James Blevens, Mary resists her mother's pleas to return home and pursues her medical career in the capital's hospitals.
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